Hypofractionated radiotherapy in the treatment of diffuse intrinsic pontine glioma in children: a single institution's experience

Details

Serval ID
serval:BIB_C47A81EE7155
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Hypofractionated radiotherapy in the treatment of diffuse intrinsic pontine glioma in children: a single institution's experience
Title of the conference
15th Annual Meeting of the Scientific Association of Swiss Radiation Oncology
Author(s)
Negretti L., Bouchireb K., Levy-Piedbois C., Habrand J.L., Dhermain F., Kalifa C., Grill J., Dufour C.
Address
Geneva, Switzerland, March 31-April 2, 2011
ISBN
0179-7158
Publication state
Published
Issued date
2011
Volume
187
Series
Strahlentherapie und Onkologie
Pages
520
Language
english
Notes
Publication type : Meeting Abstract
Abstract
Objective: To demonstrate our institutional experience in the treatment ofdiffuse intrinsic pontine glioma (DIPG) with an hypofractionated external beam radiotherapy schedule.Materials and Methods: Between April 1996 and January 2004, 22 patients, ages 2.9-12.5 years, with newly diagnosed DIPG were treated by hypofractionated radiation therapy delivering a total dose of 45 Gy in daily fraction of 3 Gy, given over 3 weeks. No other treatment was applied concomittently.Results: Fourteen of the 22 patients received the prescribed dose of 45 Gy in 15 fractions of 3 Gy, two patients received a total dose of 60 and 45 Gy with a combination of two different beams (photons and neutrons), in 5 cases the daily fraction was modified to 2 Gy because of bad tolerance and one patient died due to serious intracranial hypertension after 2 fractions of 3 Gy and one of 2 Gy. Fourteen patients of 22 patients/of the total showed a clinical improvement, usually starting in the second week of treatment. No grade 3 or 4 acute toxicity from radiotherapy was observed. No treatment interruption was needed. In six patients, steroids could be discontinued within one month after the end of radiotherapy. The median time to progression and the median overall survival were 5.7 months and 7.6 months, respectively.Conclusion: External radiotherapy with a radical hypofractionated regimen is feasible and well tolerated in children with newly diagnosed DIPG. This regimen does not seem however to change the overall survival in this setting. It could represent an alternative option of short duration to more protracted regimens.
Keywords
,
Web of science
Create date
23/09/2011 14:17
Last modification date
20/08/2019 15:39
Usage data