Biochemical markers of excitability in human neocortex

Details

Serval ID
serval:BIB_C477856E2A32
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Biochemical markers of excitability in human neocortex
Journal
Canadian Journal of Neurological Sciences
Author(s)
Sherwin  A. L., Vernet  O., Dubeau  F., Olivier  A.
ISSN
0317-1671 (Print)
Publication state
Published
Issued date
11/1991
Volume
18
Number
4 Suppl
Pages
640-4
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Nov
Abstract
We measured biochemical markers of excitability in brain excised for neurosurgical therapy of epilepsy. Intraoperative electrocorticography was used to identify and compare samples from regions of persistent interictal spike discharges and areas of the cerebral convexity which were free of interictal spiking. We found that interictal spiking was associated with elevated tissue levels of the excitatory amino acids glutamic acid (26%, p less than 0.001) and aspartic acid (25%, p less than 0.05). There was also a significant increase in the activity of the enzymes glutamic acid dehydrogenase (20%, p less than 0.01) and aspartate acid aminotransferase (18%, p less than 0.01) which are involved in their formation. There was no change in the levels of the inhibitory neurotransmitters GABA or taurine. We also found a significant increase in the activity of tyrosine hydroxylase (52%, p less than 0.001), the rate controlling enzyme in catecholamine biosynthesis. There was a reduction in the density (Bmax) of cortical alpha-1 adrenoceptors (26%, p less than 0.01) and a concomitant diminution of receptor coupled phosphatidylinositide metabolism (21%, p less than 0.01). This blunting of inhibitory noradrenergic transmembrane signaling may contribute to a relative imbalance between excitatory and inhibitory mechanisms in epileptogenic neocortex.
Keywords
Amino Acids/metabolism Biological Markers Cerebral Cortex/*physiology/physiopathology Epilepsy/*physiopathology Humans Norepinephrine/physiology Phosphatidylinositols/metabolism
Pubmed
Web of science
Create date
25/01/2008 14:13
Last modification date
20/08/2019 16:39
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