Loss to follow-up in an international, multicentre observational study.
Details
Serval ID
serval:BIB_C465F84045D1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Loss to follow-up in an international, multicentre observational study.
Journal
Hiv Medicine
Working group(s)
EuroSIDA study group
Contributor(s)
Losso M., Duran A., Vetter N., Karpov I., Vassilenko A., Mitsura VM., Suetnov O., Clumeck N., De Wit S., Poll B., Colebunders R., Kostov K., Begovac J., Machala L., Rozsypal H., Sedlacek D., Nielsen J., Lundgren J., Benfield T., Kirk O., Gerstoft J., Katzenstein T., Hansen AB., Skinhøj P., Pedersen C., Oestergaard L., Zilmer K., Smidt J., Ristola M., Katlama C., Viard JP., Girard PM., Livrozet JM., Vanhems P., Pradier C., Dabis F., Neau D., Rockstroh J., Schmidt R., van Lunzen J., Degen O., Stellbrink HJ., Staszewski S., Bogner J., Fätkenheuer G., Kosmidis J., Gargalianos P., Xylomenos G., Perdios J., Panos G., Filandras A., Karabatsaki E., Sambattakou H., Banhegyi D., Mulcahy F., Yust I., Turner D., Burke M., Pollack S., Hassoun G., Maayan S., Chiesi A., Esposito R., Mazeu I., Mussini C., Arici C., Pristera R., Mazzotta F., Gabbuti A., Vullo V., Lichtner M., Chirianni A., Montesarchio E., Gargiulo M., Antonucci G., Iacomi F., Narciso P., Vlassi C., Zaccarelli M., Lazzarin A., Finazzi R., Galli M., Ridolfo A., d'Arminio Monforte A., Rozentale B., Aldins P., Chaplinskas S., Hemmer R., Staub T., Reiss P., Bruun J., Maeland A., Ormaasen V., Knysz B., Gasiorowski J., Horban A., Prokopowicz D., Wiercinska-Drapalo A., Boron-Kaczmarska A., Pynka M., Beniowski M., Mularska E., Trocha H., Antunes F., Valadas E., Mansinho K., Maltez F., Duiculescu D., Babes V., Rakhmanova A., Vinogradova E., Buzunova S., Jevtovic D., Mokrás M., Staneková D., González-Lahoz J., Soriano V., Martin-Carbonero L., Labarga P., Clotet B., Jou A., Conejero J., Tural C., Gatell JM., Miró JM., Domingo P., Gutierrez M., Mateo G., Sambeat MA., Karlsson A., Persson PO., Flamholc L., Ledergerber B., Weber R., Francioli P., Cavassini M., Hirschel B., Boffi E., Furrer H., Battegay M., Elzi L., Kravchenko E., Chentsova N., Barton S., Johnson AM., Mercey D., Phillips A., Johnson MA., Mocroft A., Murphy M., Weber J., Scullard G., Fisher M., Brettle R., Clotet B., Antunes F., Clotet B., Duiculescu D., Gatell J., Gazzard B., Horban A., Karlsson A., Katlama C., Ledergerber B., D'Arminio Montforte A., Phillips A., Rakhmanova A., Reiss P., Rockstroh J., Lundgren J., Kirk O., Mocroft A., Friis-Møller N., Cozzi-Lepri A., Bannister W., Ellefson M., Borch A., Podlekareva D., Holkmann Olsen C., Kjaer J., Peters L., Reekie J.
ISSN
1464-2662 (Print)
ISSN-L
1464-2662
Publication state
Published
Issued date
05/2008
Peer-reviewed
Oui
Volume
9
Number
5
Pages
261-269
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
OBJECTIVE: The aim of this work was to assess loss to follow-up (LTFU) in EuroSIDA, an international multicentre observational cohort study.
METHODS: LTFU was defined as no follow-up visit, CD4 cell count measurement or viral load measurement after 1 January 2006. Poisson regression was used to describe factors related to LTFU.
RESULTS: The incidence of LTFU in 12 304 patients was 3.72 per 100 person-years of follow-up [95% confidence interval (CI) 3.58-3.86; 2712 LTFU] and varied among countries from 0.67 to 13.35. After adjustment, older patients, those with higher CD4 cell counts, and those who had started combination antiretroviral therapy all had lower incidences of LTFU, while injecting drug users had a higher incidence of LTFU. Compared with patients from Southern Europe and Argentina, patients from Eastern Europe had over a twofold increased incidence of LTFU after adjustment (incidence rate ratio 2.16; 95% CI 1.84-2.53; P<0.0001). A total of 2743 patients had a period of >1 year with no CD4 cell count or viral load measured during the year; 743 (27.1%) subsequently returned to follow-up.
CONCLUSIONS: Some patients thought to be LTFU may have died, and efforts should be made to ascertain vital status wherever possible. A significant proportion of patients who have a year with no follow-up visit, CD4 cell count measurement or viral load measurement subsequently return to follow-up.
METHODS: LTFU was defined as no follow-up visit, CD4 cell count measurement or viral load measurement after 1 January 2006. Poisson regression was used to describe factors related to LTFU.
RESULTS: The incidence of LTFU in 12 304 patients was 3.72 per 100 person-years of follow-up [95% confidence interval (CI) 3.58-3.86; 2712 LTFU] and varied among countries from 0.67 to 13.35. After adjustment, older patients, those with higher CD4 cell counts, and those who had started combination antiretroviral therapy all had lower incidences of LTFU, while injecting drug users had a higher incidence of LTFU. Compared with patients from Southern Europe and Argentina, patients from Eastern Europe had over a twofold increased incidence of LTFU after adjustment (incidence rate ratio 2.16; 95% CI 1.84-2.53; P<0.0001). A total of 2743 patients had a period of >1 year with no CD4 cell count or viral load measured during the year; 743 (27.1%) subsequently returned to follow-up.
CONCLUSIONS: Some patients thought to be LTFU may have died, and efforts should be made to ascertain vital status wherever possible. A significant proportion of patients who have a year with no follow-up visit, CD4 cell count measurement or viral load measurement subsequently return to follow-up.
Keywords
Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count/methods, Europe/epidemiology, Female, Follow-Up Studies, HIV Infections/epidemiology, HIV-1, Humans, Incidence, Male, Regression Analysis, Viral Load/methods
Pubmed
Web of science
Open Access
Yes
Create date
06/03/2009 11:24
Last modification date
20/08/2019 16:39
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