Association Between Sleep Microstructure and Incident Hypertension in a Population-Based Sample: The HypnoLaus Study.

Details

Ressource 1Download: zwab201.pdf (1024.38 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_C4608C9F0209
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association Between Sleep Microstructure and Incident Hypertension in a Population-Based Sample: The HypnoLaus Study.
Journal
Journal of the American Heart Association
Author(s)
Berger M., Vakulin A., Hirotsu C., Marchi N.A., Solelhac G., Bayon V., Siclari F., Haba-Rubio J., Vaucher J., Vollenweider P., Marques-Vidal P., Lechat B., Catcheside P.G., Eckert D.J., Adams R.J., Appleton S., Heinzer R.
ISSN
2047-9980 (Electronic)
ISSN-L
2047-9980
Publication state
Published
Issued date
19/07/2022
Peer-reviewed
Oui
Volume
11
Number
14
Pages
e025828
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Background Poor sleep quality is associated with increased incident hypertension. However, few studies have investigated the impact of objective sleep structure parameters on hypertension. This study investigated the association between sleep macrostructural and microstructural parameters and incident hypertension in a middle- to older-aged sample. Methods and Results Participants from the HypnoLaus population-based cohort without hypertension at baseline were included. Participants had at-home polysomnography at baseline, allowing assessment of sleep macrostructure (nonrapid eye movement sleep stages 1, 2, and 3; rapid eye movement sleep stages; and total sleep time) and microstructure including power spectral density of electroencephalogram in nonrapid eye movement sleep and spindles characteristics (density, duration, frequency, amplitude) in nonrapid eye movement sleep stage 2. Associations between sleep macrostructure and microstructure parameters at baseline and incident clinical hypertension over a mean follow-up of 5.2 years were assessed with multiple-adjusted logistic regression. A total of 1172 participants (42% men; age 55±10 years) were included. Of these, 198 (17%) developed hypertension. After adjustment for confounders, no sleep macrostructure features were associated with incident hypertension. However, low absolute delta and sigma power were significantly associated with incident hypertension where participants in the lowest quartile of delta and sigma had a 1.69-fold (95% CI, 1.00-2.89) and 1.72-fold (95% CI, 1.05-2.82) increased risk of incident hypertension, respectively, versus those in the highest quartile. Lower spindle density (odds ratio, 0.87; 95% CI, 0.76-0.99) and amplitude (odds ratio, 0.98; 95% CI, 0.95-1.00) were also associated with higher incident hypertension. Conclusions Sleep microstructure is associated with incident hypertension. Slow-wave activity and sleep spindles, 2 hallmarks of objective sleep continuity and quality, were inversely and consistently associated with incident hypertension. This supports the protective role of sleep continuity in the development of hypertension.
Keywords
Aged, Electroencephalography, Female, Humans, Hypertension/diagnosis, Hypertension/epidemiology, Male, Middle Aged, Polysomnography, Sleep, Sleep, REM, delta power, hypertension, power spectral density, sleep architecture, sleep structure, slow wave sleep, spindle
Pubmed
Open Access
Yes
Create date
03/08/2022 10:40
Last modification date
28/09/2022 11:13
Usage data