ESRD caused by nephrolithiasis: prevalence, mechanisms, and prevention.

Details

Serval ID
serval:BIB_C45EEE959796
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
ESRD caused by nephrolithiasis: prevalence, mechanisms, and prevention.
Journal
American Journal of Kidney Diseases
Author(s)
Jungers P., Joly D., Barbey F., Choukroun G., Daudon M.
ISSN
1523-6838 (Electronic)
ISSN-L
0272-6386
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
44
Number
5
Pages
799-805
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
BACKGROUND: The contribution of nephrolithiasis-related end-stage renal disease (ESRD) to patients requiring renal replacement therapy has never been specifically evaluated.
METHODS: Of the entire cohort of 1,391 consecutive patients who started maintenance dialysis therapy at our nephrology department between January 1989 and December 2000, a total of 45 patients (21 men) had renal stone disease as the cause of ESRD and constitute the study material. Type and cause of renal stone disease was determined in the 45 patients, as well as the change in prevalence of nephrolithiasis-related ESRD with time during this 12-year period.
RESULTS: The overall proportion of nephrolithiasis-related ESRD was 3.2%. Infection (struvite) stones accounted for 42.2%; calcium stones, 26.7%; uric acid nephrolithiasis, 17.8%; and hereditary diseases (including primary hyperoxaluria type 1 and cystinuria), 13.3% of cases. Women were predominant among patients with infection and calcium stones, whereas men were predominant among patients with uric acid or hereditary stone disease. The proportion of patients with nephrolithiasis-related ESRD decreased from 4.7% in the triennial period 1989 to 1991 to 2.2% in the most recent period, 1998 to 2000 ( P = 0.07). This tendency to a decreasing prevalence mainly was caused by a rarefaction of infection and calcium stones with time, whereas frequencies of uric acid and hereditary stone disease remained essentially unchanged.
CONCLUSION: Severe forms of nephrolithiasis remain an underestimated cause of potentially avoidable ESRD and need for renal replacement therapy. These findings highlight the crucial importance of accurate stone analysis and metabolic evaluation to provide early diagnosis and proper therapy for conditions that may lead to ESRD through recurrent stone formation and/or parenchymal crystal infiltration.
Keywords
Adult, Aged, Female, France/epidemiology, Humans, Kidney Calculi/epidemiology, Kidney Calculi/prevention & control, Kidney Failure, Chronic/etiology, Male, Middle Aged, Prevalence
Pubmed
Web of science
Create date
09/02/2012 15:13
Last modification date
20/08/2019 15:39
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