Autoimmune Gastritis in the Pediatric Age: An Underestimated Condition Report of Two Cases and Review.
Details
State: Public
Version: Final published version
Serval ID
serval:BIB_C446DEF76110
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Autoimmune Gastritis in the Pediatric Age: An Underestimated Condition Report of Two Cases and Review.
Journal
Frontiers in pediatrics
ISSN
2296-2360 (Print)
ISSN-L
2296-2360
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
6
Pages
123
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
<b>Background:</b> Diagnosis of pediatric autoimmune gastritis (AIG) in children is important due to poor outcome and risk of malignancy. This condition is often underestimated in the clinico-pathologic diagnostic work-up, leading to delayed time-to-diagnosis. To increase the awareness of this condition in the pediatric population, we present two cases encountered at our institution, discuss their clinical, biological, and histological presentations in relation with evidence from the literature, and propose an algorithm for diagnosis and follow-up of AIG in children. <b>Case presentation:</b> Two patients (12 and 17 years old) presented with iron deficiency anemia and negative family history for autoimmune disorders. In both cases, the final diagnosis of autoimmune gastritis was delayed until pathological examination of endoscopic gastric biopsies showed atrophy of oxyntic glands. <i>Helicobacter pylori</i> search was negative. Follow up biopsies revealed persistent disease. Literature review on this condition shows unclear etiology and poor long term outcome in some patients because of increased risk of malignancy. <b>Conclusions:</b> AIG should be considered in the differential diagnosis of iron deficiency anemia in the pediatric population.Standardized clinico-pathologic work-up is mandatory. Endoscopic follow-up should be performed due to the risk of malignancy.
Keywords
ECL cell hyperplasia, autoimmune gastritis, children, gastric atrophy, intestinal metaplasia, iron-deficiency anemia
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2018 18:02
Last modification date
20/08/2019 16:39