Insights from thrombi retrieved in stroke due to large vessel occlusion

Details

Serval ID
serval:BIB_C43CE1F02E5C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Insights from thrombi retrieved in stroke due to large vessel occlusion
Journal
Journal of cerebral blood flow and metabolism
Author(s)
Bacigaluppi Marco, Semerano Aurora, Gullotta Giorgia Serena, Strambo Davide
ISSN
1559-7016 ((Electronic)
ISSN-L
0271-678X
Publication state
Published
Issued date
08/2019
Peer-reviewed
Oui
Volume
39
Number
8
Pages
1433-1451
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The recent advances of endovascular procedures to treat stroke due to large cerebral vessel occlusion have made it possible to analyze the retrieved thrombus material. Analysis of cerebral thrombi is emerging as a relevant opportunity to complement the diagnostic workup of etiology, to develop new lytic approaches and to optimize the acute treatment of stroke due to large vessel occlusion. Nonetheless, retrieved thrombi are frequently discarded since their informative potential is often neglected and standards are missing. This review provides an overview of the current knowledge and expanding research relating to thrombus composition analysis in large vessel occlusions. We first discuss the heterogeneity of thrombogenic factors that underlie the thrombotic formation in stroke and its implications to identify stroke etiology and thrombus age. Further, we show that understanding structural characteristics of thrombus is pivotal for the development of new-targeted lytic therapies as well as to improve, through thrombus modeling, the development of thrombectomy devices. Finally, we discuss the on-going attempts to identify a signature of thrombus composition indirectly through imaging and peripheral blood biomarkers, which might in future assist treatment decision-making as well as secondary prevention. Thrombus analysis might contribute to the advancement and optimization of personalized stroke treatments.
Keywords
Neurology, Clinical Neurology, Cardiology and Cardiovascular Medicine Thrombus, histology, inflammation, stroke, thrombectomy
Pubmed
Web of science
Create date
24/06/2019 16:18
Last modification date
20/09/2019 5:09
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