The chemistry of branched condensed phosphates.

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Serval ID
serval:BIB_C3FB7908B34E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The chemistry of branched condensed phosphates.
Journal
Nature communications
Author(s)
Dürr-Mayer T., Qiu D., Eisenbeis V.B., Steck N., Häner M., Hofer A., Mayer A., Siegel J.S., Baldridge K.K., Jessen H.J.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
10/09/2021
Peer-reviewed
Oui
Volume
12
Number
1
Pages
5368
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Condensed phosphates may exist as linear, cyclic or branched structures. Due to their important role in nature, linear polyphosphates have been well studied. In contrast, branched phosphates (ultraphosphates) remain largely uncharacterised, because they were already described in 1950 as exceedingly unstable in the presence of water, epitomized in the antibranching-rule. This rule lacks experimental backup, since, to the best of our knowledge, no rational synthesis of defined ultraphosphates is known. Consequently, detailed studies of their chemical properties, reactivity and potential biological relevance remain elusive. Here, we introduce a general synthesis of monodisperse ultraphosphates. Hydrolysis half-lives up to days call the antibranching-rule into question. We provide evidence for the interaction of an enzyme with ultraphosphates and discover a rearrangement linearizing the branched structure. Moreover, ultraphosphate can phosphorylate nucleophiles such as amino acids and nucleosides with implications for prebiotic chemistry. Our results provide an entry point into the uncharted territory of branched condensed phosphates.
Pubmed
Web of science
Open Access
Yes
Create date
21/09/2021 10:57
Last modification date
25/09/2021 5:36
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