Impaired metabolic reactivity to oxidative stress in early psychosis patients.

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State: Public
Version: author
Serval ID
serval:BIB_C3E8F52745DF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Impaired metabolic reactivity to oxidative stress in early psychosis patients.
Journal
Schizophrenia Bulletin
Author(s)
Fournier M., Ferrari C., Baumann P.S., Polari A., Monin A., Bellier-Teichmann T., Wulff J., Pappan K.L., Cuenod M., Conus P., Do K.Q.
ISSN
1745-1701 (Electronic)
ISSN-L
0586-7614
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
40
Number
5
Pages
973-983
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
Because increasing evidence point to the convergence of environmental and genetic risk factors to drive redox dysregulation in schizophrenia, we aim to clarify whether the metabolic anomalies associated with early psychosis reflect an adaptation to oxidative stress. Metabolomic profiling was performed to characterize the response to oxidative stress in fibroblasts from control individuals (n = 20) and early psychosis patients (n = 30), and in all, 282 metabolites were identified. In addition to the expected redox/antioxidant response, oxidative stress induced a decrease of lysolipid levels in fibroblasts from healthy controls that were largely muted in fibroblasts from patients. Most notably, fibroblasts from patients showed disrupted extracellular matrix- and arginine-related metabolism after oxidative stress, indicating impairments beyond the redox system. Plasma membrane and extracellular matrix, 2 regulators of neuronal activity and plasticity, appeared as particularly susceptible to oxidative stress and thus provide novel mechanistic insights for pathophysiological understanding of early stages of psychosis. Statistically, antipsychotic medication at the time of biopsy was not accounting for these anomalies in the metabolism of patients' fibroblasts, indicating that they might be intrinsic to the disease. Although these results are preliminary and should be confirmed in a larger group of patients, they nevertheless indicate that the metabolic signature of reactivity to oxidative stress may provide reliable early markers of psychosis. Developing protective measures aimed at normalizing the disrupted pathways should prevent the pathological consequences of environmental stressors.
Pubmed
Web of science
Open Access
Yes
Create date
07/11/2014 11:22
Last modification date
20/08/2019 16:39
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