A brain-spine interface alleviating gait deficits after spinal cord injury in primates.

Details

Serval ID
serval:BIB_C387724F3B01
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A brain-spine interface alleviating gait deficits after spinal cord injury in primates.
Journal
Nature
Author(s)
Capogrosso M., Milekovic T., Borton D., Wagner F., Moraud E.M., Mignardot J.B., Buse N., Gandar J., Barraud Q., Xing D., Rey E., Duis S., Jianzhong Y., Ko W.K., Li Q., Detemple P., Denison T., Micera S., Bezard E., Bloch J., Courtine G.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
09/11/2016
Peer-reviewed
Oui
Volume
539
Number
7628
Pages
284-288
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish

Abstract
Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces have directly linked cortical activity to electrical stimulation of muscles, and have thus restored grasping abilities after hand paralysis. Theoretically, this strategy could also restore control over leg muscle activity for walking. However, replicating the complex sequence of individual muscle activation patterns underlying natural and adaptive locomotor movements poses formidable conceptual and technological challenges. Recently, it was shown in rats that epidural electrical stimulation of the lumbar spinal cord can reproduce the natural activation of synergistic muscle groups producing locomotion. Here we interface leg motor cortex activity with epidural electrical stimulation protocols to establish a brain-spine interface that alleviated gait deficits after a spinal cord injury in non-human primates. Rhesus monkeys (Macaca mulatta) were implanted with an intracortical microelectrode array in the leg area of the motor cortex and with a spinal cord stimulation system composed of a spatially selective epidural implant and a pulse generator with real-time triggering capabilities. We designed and implemented wireless control systems that linked online neural decoding of extension and flexion motor states with stimulation protocols promoting these movements. These systems allowed the monkeys to behave freely without any restrictions or constraining tethered electronics. After validation of the brain-spine interface in intact (uninjured) monkeys, we performed a unilateral corticospinal tract lesion at the thoracic level. As early as six days post-injury and without prior training of the monkeys, the brain-spine interface restored weight-bearing locomotion of the paralysed leg on a treadmill and overground. The implantable components integrated in the brain-spine interface have all been approved for investigational applications in similar human research, suggesting a practical translational pathway for proof-of-concept studies in people with spinal cord injury.

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Create date
05/12/2016 18:53
Last modification date
20/08/2019 15:38
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