The influence of time after stroke on brain activations during a motor task.

Details

Serval ID
serval:BIB_C31E2AFAD046
Type
Article: article from journal or magazin.
Collection
Publications
Title
The influence of time after stroke on brain activations during a motor task.
Journal
Annals of Neurology
Author(s)
Ward N.S., Brown M.M., Thompson A.J., Frackowiak R.S.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Publication state
Published
Issued date
2004
Volume
55
Number
6
Pages
829-834
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
After stroke, the pattern of brain activation during performance of a motor task is related to outcome. Here, we compare this relationship in the early (10-14 days) and late (at least 3 months) phases after first-ever stroke. A negative linear relationship between task-related brain activation, as measured by functional magnetic resonance imaging, and outcome is seen in several identical primary and nonprimary motor regions that is independent of time after stroke. In other words, patients with poorer outcome scores recruit more widely within motor-related regions in both the early or late poststroke phase. However, in contralesional middle intraparietal sulcus, contralesional cerebellum, and ipsilesional rostral premotor cortex, this relationship is seen only in the early poststroke phase. Thus, patients with poorer outcome scores recruit these areas in only the early and not the late poststroke phase. These results suggest that there are differences in the cerebral implementation of action in patients with poor outcome that are dependent on the time since stroke. Thus, in those patients with the most to gain from rehabilitation, different therapeutic approaches may be required at different stages after stroke.
Keywords
Adult, Aged, Brain/anatomy & histology, Brain/physiopathology, Functional Laterality/physiology, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Middle Aged, Motor Skills/physiology, Random Allocation, Recovery of Function, Stroke/physiopathology, Time Factors
Pubmed
Web of science
Create date
11/09/2011 18:32
Last modification date
20/08/2019 15:38
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