From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.

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Version: Final published version
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Serval ID
serval:BIB_C3142A773692
Type
Article: article from journal or magazin.
Collection
Publications
Title
From protein sequences to 3D-structures and beyond: the example of the UniProt knowledgebase.
Journal
Cellular and Molecular Life Sciences
Author(s)
Hinz U.
Working group(s)
UniProt Consortium
Contributor(s)
Apweiler R., Martin MJ., O'Donovan C., Magrane M., Alam-Faruque Y., Antunes R., Barrell D., Bely B., Bingley M., Binns D., Bower L., Browne P., Chan WM., Dimmer E., Eberhardt R., Fedotov A., Foulger R., Garavelli J., Huntley R., Jacobsen J., Kleen M., Laiho K., Leinonen R., Legge D., Lin Q., Liu W., Luo J., Orchard S., Patient S., Poggioli D., Pruess M., Corbett M., di Martino G., Donnelly M., van Rensburg P., Bairoch A., Bougueleret L., Xenarios I., Altairac S., Auchincloss A., Argoud-Puy G., Axelsen K., Baratin D., Blatter MC., Boeckmann B., Bolleman J., Bollondi L., Boutet E., Quintaje SB., Breuza L., Bridge A., de Castro E., Ciapina L., Coral D., Coudert E., Cusin I., David F., Delbard G., Doche M., Dornevil D., Roggli PD., Duvaud S., Estreicher A., Famiglietti L., Feuermann M., Gehant S., Farriol-Mathis N., Ferro S., Gasteiger E., Gateau A., Gerritsen V., Gos A., Gruaz-Gumowski N., Hinz U., Hulo C., Hulo N., James J., Jimenez S., Jungo F., Kappler T., Keller G., Lachaize C., Lane-Guermonprez L., Langendijk-Genevaux P., Lara V., Lemercier P., Lieberherr D., Lima Tde O., Mangold V., Martin X., Masson P., Moinat M., Morgat A., Mottaz A., Paesano S., Pedruzzi I., Pilbout S., Pillet V., Poux S., Pozzato M., Redaschi N., Rivoire C., Roechert B., Schneider M., Sigrist C., Sonesson K., Staehli S., Stanley E., Stutz A., Sundaram S., Tognolli M., Verbregue L., Veuthey AL., Yip L., Zuletta L., Wu C., Arighi C., Arminski L., Barker W., Chen C., Chen Y., Hu ZZ., Huang H., Mazumder R., McGarvey P., Natale DA., Nchoutmboube J., Petrova N., Subramanian N., Suzek BE., Ugochukwu U., Vasudevan S., Vinayaka CR., Yeh LS., Zhang J.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Publication state
Published
Issued date
2010
Volume
67
Number
7
Pages
1049-1064
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
Publication Status: ppublish
Abstract
With the dramatic increase in the volume of experimental results in every domain of life sciences, assembling pertinent data and combining information from different fields has become a challenge. Information is dispersed over numerous specialized databases and is presented in many different formats. Rapid access to experiment-based information about well-characterized proteins helps predict the function of uncharacterized proteins identified by large-scale sequencing. In this context, universal knowledgebases play essential roles in providing access to data from complementary types of experiments and serving as hubs with cross-references to many specialized databases. This review outlines how the value of experimental data is optimized by combining high-quality protein sequences with complementary experimental results, including information derived from protein 3D-structures, using as an example the UniProt knowledgebase (UniProtKB) and the tools and links provided on its website ( http://www.uniprot.org/ ). It also evokes precautions that are necessary for successful predictions and extrapolations.
Keywords
Binding Sites, Catalytic Domain, Databases, Protein, Knowledge Bases, Protein Conformation, Proteins/chemistry, Proteins/genetics, Sequence Analysis, Protein
Pubmed
Web of science
Open Access
Yes
Create date
11/03/2011 12:20
Last modification date
20/08/2019 15:38
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