Rôle de l'EGFR dans le cancer pulmonaire non à petites cellules [The role of EGFR in non-small cell lung carcinoma]

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Serval ID
serval:BIB_C2178AFE20D3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rôle de l'EGFR dans le cancer pulmonaire non à petites cellules [The role of EGFR in non-small cell lung carcinoma]
Journal
Revue Médicale Suisse
Author(s)
Peters S., Betticher D.C.
ISSN
1660-9379
Publication state
Published
Issued date
2009
Volume
5
Number
204
Pages
1096-1101
Language
french
Abstract
EGFR receptor is expressed on most of the non small cell lung carcinoma (NSCLC) cells. Its relative importance in oncogenesis and tumour progression seems to greatly vary among NSCLC. Two molecules targeting differently EGFR are currently used for the treatment of metastatic NSCLC. cetuximab, a monoclonal antibody directed against the extracellular domain of the receptor, leads to a moderate survival benefit when associated with standard first-line chemotherapy. Erlotinib, a small EGFR tyrosine-kinase inhibitor molecule is used in 2nd or 3rd treatment line. Predictive factors for efficiency of these new treatments are subjects of intense research, in order to allow a better selection of the patients who could benefit from such a strategy.
Keywords
Antineoplastic Agents/therapeutic use, Carcinoma, Non-Small-Cell Lung/drug therapy, Carcinoma, Non-Small-Cell Lung/metabolism, Humans, Lung Neoplasms/drug therapy, Lung Neoplasms/metabolism, Receptor, Epidermal Growth Factor/antagonists & inhibitors, Receptor, Epidermal Growth Factor/metabolism
Pubmed
Create date
08/01/2010 15:21
Last modification date
20/08/2019 15:37
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