Sympathectomy potentiates the vasoconstrictor response to nitric oxide synthase inhibition in humans

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Serval ID
serval:BIB_C1D7A78C6D01
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sympathectomy potentiates the vasoconstrictor response to nitric oxide synthase inhibition in humans
Journal
Cardiovascular Research
Author(s)
Lepori  M., Sartori  C., Duplain  H., Nicod  P., Scherrer  U.
ISSN
0008-6363 (Print)
Publication state
Published
Issued date
08/1999
Volume
43
Number
3
Pages
739-43
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 15
Abstract
OBJECTIVE: Nitric oxide exerts its cardiovascular actions at least in part by modulation of the sympathetic vasoconstrictor tone. There is increasing evidence that nitric oxide inhibits central neural sympathetic outflow, and preliminary evidence suggests that it may also modulate peripheral sympathetic vasoconstrictor tone. METHODS: To test this latter concept, in six subjects having undergone thoracic sympathectomy for hyperhydrosis, we compared the vascular responses to systemic L-NMMA infusion (1 mg/kg/min over 10 min) in the innervated and the denervated limb. We also studied vascular responses to the infusion of the non-nitric-oxide-dependent vasoconstrictor phenylephrine. RESULTS: L-NMMA infusion evoked a roughly 3-fold larger increase in vascular resistance in the denervated forearm than in the innervated calf. In the denervated forearm, vascular resistance increased by 58 +/- 10 percent (mean +/- SE), whereas in the innervated calf it increased only by 21 +/- 6 percent (P < 0.01, forearm vs. calf). This augmented vasoconstrictor response was specific for L-NMMA, and not related to augmented non-specific vasoconstrictor responsiveness secondary to sympathectomy, because phenylephrine infusion increased vascular resistance similarly in the denervated forearm and the innervated calf (by 24 +/- 7, and 29 +/- 8 percent, respectively). The augmented vasoconstrictor response was related specifically to denervation, because in control subjects, the vasoconstrictor responses to L-NMMA were comparable in the forearm and the calf. CONCLUSIONS: These findings indicate that in the absence of sympathetic innervation, the vasoconstrictor responses to nitric oxide synthase inhibition are augmented.
Keywords
Adult Arginine/diagnostic use Case-Control Studies Enzyme Inhibitors/*diagnostic use Female Forearm/blood supply Humans Hyperhidrosis/surgery Leg/blood supply Male Nitric Oxide Synthase/*antagonists & inhibitors Phenylephrine/diagnostic use Regional Blood Flow/drug effects *Sympathectomy Vascular Resistance/*drug effects Vasoconstrictor Agents/diagnostic use omega-N-Methylarginine/*diagnostic use
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:44
Last modification date
25/09/2019 7:10
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