Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype

Details

Serval ID
serval:BIB_C19CA8B621F1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Fluconazole-resistant recurrent oral candidiasis in human immunodeficiency virus-positive patients: persistence of Candida albicans strains with the same genotype
Journal
Journal of Clinical Microbiology
Author(s)
Millon  L., Manteaux  A., Reboux  G., Drobacheff  C., Monod  M., Barale  T., Michel-Briand  Y.
ISSN
0095-1137 (Print)
Publication state
Published
Issued date
04/1994
Volume
32
Number
4
Pages
1115-8
Notes
Journal Article --- Old month value: Apr
Abstract
Thirty human immunodeficiency virus-positive patients carrying Candida albicans in their oropharynx were treated with fluconazole and were monitored for 90 to 570 days. Fluconazole-resistant C. albicans (MIC, > 32 micrograms/ml) appeared only in seven patients and only after 90 days of treatment corresponding to a total dose of more than 10 g. Resistance was not associated with resistance to other azole derivatives. Susceptible and resistant strains from each patient had the same genotype (as defined by electrophoretic karyotype and restriction fragment length polymorphism). Thus, the resistant strains were selected by the antimycotic treatment from the susceptible strain present in each case.
Keywords
AIDS-Related Opportunistic Infections/complications/*drug therapy/microbiology Candida albicans/drug effects/genetics/isolation & purification Candidiasis, Oral/complications/*drug therapy/microbiology Drug Resistance, Microbial Fluconazole/*therapeutic use Genotype Humans Recurrence Time Factors
Pubmed
Web of science
Create date
25/01/2008 17:46
Last modification date
03/03/2018 21:08
Usage data