Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.

Details

Serval ID
serval:BIB_C18B8B18F158
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.
Journal
Clinical microbiology reviews
Author(s)
Poirel L., Jayol A., Nordmann P.
ISSN
1098-6618 (Electronic)
ISSN-L
0893-8512
Publication state
Published
Issued date
04/2017
Peer-reviewed
Oui
Volume
30
Number
2
Pages
557-596
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
SUMMARYPolymyxins are well-established antibiotics that have recently regained significant interest as a consequence of the increasing incidence of infections due to multidrug-resistant Gram-negative bacteria. Colistin and polymyxin B are being seriously reconsidered as last-resort antibiotics in many areas where multidrug resistance is observed in clinical medicine. In parallel, the heavy use of polymyxins in veterinary medicine is currently being reconsidered due to increased reports of polymyxin-resistant bacteria. Susceptibility testing is challenging with polymyxins, and currently available techniques are presented here. Genotypic and phenotypic methods that provide relevant information for diagnostic laboratories are presented. This review also presents recent works in relation to recently identified mechanisms of polymyxin resistance, including chromosomally encoded resistance traits as well as the recently identified plasmid-encoded polymyxin resistance determinant MCR-1. Epidemiological features summarizing the current knowledge in that field are presented.

Keywords
Anti-Bacterial Agents/pharmacology, Anti-Bacterial Agents/therapeutic use, Chromosomes/genetics, Drug Resistance, Multiple, Bacterial/drug effects, Drug Resistance, Multiple, Bacterial/genetics, Gram-Negative Bacteria/drug effects, Gram-Negative Bacteria/genetics, Gram-Negative Bacterial Infections/drug therapy, Humans, Plasmids/genetics, Polymyxins/pharmacology, Polymyxins/therapeutic use, Gram-negative bacteria, MCR-1, lipopolysaccharide, polymyxins, toxicity
Pubmed
Web of science
Open Access
Yes
Create date
21/03/2017 19:13
Last modification date
20/08/2019 15:36
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