Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease.

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State: Public
Version: author
Serval ID
serval:BIB_C1631EB9C20E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease.
Journal
Journal of Neurochemistry
Author(s)
Popp J., Lewczuk P., Kölsch H., Meichsner S., Maier W., Kornhuber J., Jessen F., Lütjohann D.
ISSN
1471-4159 (Electronic)
ISSN-L
0022-3042
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
123
Number
2
Pages
310-316
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Abstract
Disturbances of the cholesterol metabolism are associated with Alzheimer's disease (AD) risk and related cerebral pathology. Experimental studies found changing levels of cholesterol and its metabolites 24S-hydroxycholesterol (24S-OHC) and 27-hydroxycholesterol (27-OHC) to contribute to amyloidogenesis by increasing the production of soluble amyloid precursor protein (sAPP). The aim of this study was to evaluate the relationship between the CSF and circulating cholesterol 24S-OHC and 27-OHC, and the sAPP production as measured by CSF concentrations of sAPP forms in humans. The plasma and the CSF concentrations of cholesterol, 24S-OHC and 27-OHC, and the CSF concentrations of sAPPα, sAPPβ, and Aß1-42 were assessed in subjects with AD and controls with normal cognition. In multivariate regression tests including age, gender, albumin ratio, and apolipoprotein E (APOE)ε4 status CSF cholesterol, 24S-OHC, and 27-OHC independently predicted the concentrations of sAPPα and sAPPβ. The associations remained significant when analyses were separately performed in the AD group. Furthermore, plasma 27-OHC concentrations were associated with the CSF sAPP levels. The results suggest that high CSF concentrations of cholesterol, 24S-OHC, and 27-OHC are associated with increased production of both sAPP forms in AD.
Keywords
Aged, Alzheimer Disease/diagnosis, Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/biosynthesis, Biological Markers/blood, Biological Markers/cerebrospinal fluid, Cholesterol/metabolism, Female, Humans, Hydroxycholesterols/metabolism, Male, Middle Aged, Up-Regulation/physiology
Pubmed
Web of science
Open Access
Yes
Create date
02/08/2012 13:18
Last modification date
20/08/2019 16:36
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