Allergologie-immunologie: Effets secondaires des immunothérapies du cancer : du travail pour l’immunologue clinique [Side effects of cancer immunotherapies : important role for the clinical immunologist]

Details

Serval ID
serval:BIB_C148880B688D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Allergologie-immunologie: Effets secondaires des immunothérapies du cancer : du travail pour l’immunologue clinique [Side effects of cancer immunotherapies : important role for the clinical immunologist]
Journal
Revue medicale suisse
Author(s)
Obeid M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
09/01/2019
Peer-reviewed
Oui
Volume
15
Number
N° 632-633
Pages
17-19
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The immune checkpoint inhibitors (ICI) have radically changed the treatment and the prognostic of certain types of cancer. This reprogramming of the immune system can sometimes lead to immuno-related adverse events (irAEs) involving, depending on the immunotherapy used, multiple organ (s) with different severity, frequency and chronology. In theory all organs can be affected, often in a reversible and rapid manner if an immunosuppressive therapy is initiated in time. In contrast, endocrinopathies and some neuropathies are of long lasting and sometimes of irreversible nature. The management of high-grade autoimmune toxicities requires, first, the suspension of treatment and second, the introduction of steroids as first-line or, in case of failure, of a second immunosuppressive agent.
Keywords
Drug-Related Side Effects and Adverse Reactions, Humans, Immunologic Factors, Immunosuppressive Agents, Immunotherapy/adverse effects, Neoplasms/therapy
Pubmed
Create date
10/02/2019 16:34
Last modification date
20/08/2019 16:36
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