EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis.

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Version: Final published version
Secondary document(s)
Download: mmc1 (16).pdf (574.25 [Ko])
State: Public
Version: Supplementary document
Download: mmc2 (4).pdf (2783.29 [Ko])
State: Public
Version: Supplementary document
Serval ID
serval:BIB_C112D80A9534
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis.
Journal
Cell reports
Author(s)
Clottu A.S., Mathias A., Sailer A.W., Schluep M., Seebach J.D., Du Pasquier R., Pot C.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
03/01/2017
Peer-reviewed
Oui
Volume
18
Number
1
Pages
213-224
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4+ T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis. However, the EBI2 expression profile in human lymphocytes in both healthy and MS donors is unknown. Here, we characterize EBI2 biology in human lymphocytes. We observed that EBI2 is functionally expressed on memory CD4+ T cells and is enhanced under natalizumab treatment. These data suggest a significant role for EBI2 in human CD4+ T cell migration, notably in patients with MS. Better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.

Keywords
Adult, CD11 Antigens/metabolism, CD4-Positive T-Lymphocytes/drug effects, CD4-Positive T-Lymphocytes/metabolism, Cell Movement/drug effects, Humans, Hydroxycholesterols/pharmacology, Immunologic Memory/drug effects, Multiple Sclerosis/immunology, Multiple Sclerosis/metabolism, Multiple Sclerosis/pathology, Natalizumab/pharmacology, Natalizumab/therapeutic use, Receptors, G-Protein-Coupled/metabolism, G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2), lymphocyte trafficking, multiple sclerosis, natalizumab, oxysterols
Pubmed
Web of science
Open Access
Yes
Create date
10/01/2017 18:35
Last modification date
20/08/2019 16:35
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