Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.

Details

Serval ID
serval:BIB_C1048CB1FB57
Type
Article: article from journal or magazin.
Collection
Publications
Title
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Journal
Cancer Cell
Author(s)
Yan X., Hu Z., Feng Y., Hu X., Yuan J., Zhao S.D., Zhang Y., Yang L., Shan W., He Q., Fan L., Kandalaft L.E., Tanyi J.L., Li C., Yuan C.X., Zhang D., Yuan H., Hua K., Lu Y., Katsaros D., Huang Q., Montone K., Fan Y., Coukos G., Boyd J., Sood A.K., Rebbeck T., Mills G.B., Dang C.V., Zhang L.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
28
Number
4
Pages
529-540
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.
Pubmed
Web of science
Open Access
Yes
Create date
09/11/2015 15:08
Last modification date
20/08/2019 16:35
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