Rôle du pathologiste dans la prise en charge des tumeurs stromales gastro-intestinales (GIST) [The role of the pathologist in the management of gastrointestinal stromal tumors (GIST)]

Details

Serval ID
serval:BIB_C0E36FF2F6F7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Rôle du pathologiste dans la prise en charge des tumeurs stromales gastro-intestinales (GIST) [The role of the pathologist in the management of gastrointestinal stromal tumors (GIST)]
Journal
Revue Médicale Suisse
Author(s)
Bouzourene H.
ISSN
1660-9379
Publication state
Published
Issued date
2009
Volume
5
Number
211
Pages
1505-1058
Language
french
Abstract
Considerable progress was realized these last years in the understanding of the molecular mechanisms and the treatment of the GIST. Their diagnosis remains based on the morphology and immunohistochemistry. The evaluation of GIST prognosis was till know difficult to establish but a new histopronostic classification currently used allows a better therapeutic approach. The search for KIT and PDGFRA mutations is recommended to adapt a targeted therapy by KIT inhibitors. The pathologist plays a crucial role in the management of the GIST because it is on him that is based the diagnosis, the evaluation of the prognosis and the treatment (surgery and kit inhibitors).
Keywords
Gastrointestinal Stromal Tumors/genetics, Gastrointestinal Stromal Tumors/pathology, Humans, Protein Kinase Inhibitors/therapeutic use, Proto-Oncogene Proteins c-kit/genetics, Receptor, Platelet-Derived Growth Factor alpha/genetics
Pubmed
Create date
01/10/2009 10:37
Last modification date
20/08/2019 16:35
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