Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Graff, M.; Scott, R.A.; Justice, A.E.; Young, K.L.; Feitosa, M.F.; Barata, L.; Winkler, T.W.; Chu, A.Y.; Mahajan, A.; Hadley, D.; Xue, L.; Workalemahu, T.; Heard-Costa, N.L.; den Hoed, M.; Ahluwalia, T.S.; Qi, Q.; Ngwa, J.S.; Renström, F.; Quaye, L.; Eicher, J.D.; Hayes, J.E.; Cornelis, M.; Kutalik, Z.; Lim, E.; Luan, J.; Huffman, J.E.; Zhang, W.; Zhao, W.; Griffin, P.J.; Haller, T.; Ahmad, S.; Marques-Vidal, P.M.; Bien, S.; Yengo, L.; Teumer, A.; Smith, A.V.; Kumari, M.; Harder, M.N.; Justesen, J.M.; Kleber, M.E.; Hollensted, M.; Lohman, K.; Rivera, N.V.; Whitfield, J.B.; Zhao, J.H.; Stringham, H.M.; Lyytikäinen, L.P.; Huppertz, C.; Willemsen, G.; Peyrot, W.J.; Wu, Y.; Kristiansson, K.; Demirkan, A.; Fornage, M.; Hassinen, M.; Bielak, L.F.; Cadby, G.; Tanaka, T.; Mägi, R.; van der Most, P.J.; Jackson, A.U.; Bragg-Gresham, J.L.; Vitart, V.; Marten, J.; Navarro, P.; Bellis, C.; Pasko, D.; Johansson, Å.; Snitker, S.; Cheng, Y.C.; Eriksson, J.; Lim, U.; Aadahl, M.; Adair, L.S.; Amin, N.; Balkau, B.; Auvinen, J.; Beilby, J.; Bergman, R.N.; Bergmann, S.; Bertoni, A.G.; Blangero, J.; Bonnefond, A.; Bonnycastle, L.L.; Borja, J.B.; Brage, S.; Busonero, F.; Buyske, S.; Campbell, H.; Chines, P.S.; Collins, F.S.; Corre, T.; Smith, G.D.; Delgado, G.E.; Dueker, N.; Dörr, M.; Ebeling, T.; Eiriksdottir, G.; Esko, T.; Faul, J.D.; Fu, M.; Færch, K.; Gieger, C.; Gläser, S.; Gong, J.; Gordon-Larsen, P.; Grallert, H.; Grammer, T.B.; Grarup, N.; van Grootheest, G.; Harald, K.; Hastie, N.D.; Havulinna, A.S.; Hernandez, D.; Hindorff, L.; Hocking, L.J.; Holmens, O.L.; Holzapfel, C.; Hottenga, J.J.; Huang, J.; Huang, T.; Hui, J.; Huth, C.; Hutri-Kähönen, N.; James, A.L.; Jansson, J.O.; Jhun, M.A.; Juonala, M.; Kinnunen, L.; Koistinen, H.A.; Kolcic, I.; Komulainen, P.; Kuusisto, J.; Kvaløy, K.; Kähönen, M.; Lakka, T.A.; Launer, L.J.; Lehne, B.; Lindgren, C.M.; Lorentzon, M.; Luben, R.; Marre, M.; Milaneschi, Y.; Monda, K.L.; Montgomery, G.W.; De Moor, MHM; Mulas, A.; Müller-Nurasyid, M.; Musk, A.W.; Männikkö, R.; Männistö, S.; Narisu, N.; Nauck, M.; Nettleton, J.A.; Nolte, I.M.; Oldehinkel, A.J.; Olden, M.; Ong, K.K.; Padmanabhan, S.; Paternoster, L.; Perez, J.; Perola, M.; Peters, A.; Peters, U.; Peyser, P.A.; Prokopenko, I.; Puolijoki, H.; Raitakari, O.T.; Rankinen, T.; Rasmussen-Torvik, L.J.; Rawal, R.; Ridker, P.M.; Rose, L.M.; Rudan, I.; Sarti, C.; Sarzynski, M.A.; Savonen, K.; Scott, W.R.; Sanna, S.; Shuldiner, A.R.; Sidney, S.; Silbernagel, G.; Smith, B.H.; Smith, J.A.; Snieder, H.; Stančáková, A.; Sternfeld, B.; Swift, A.J.; Tammelin, T.; Tan, S.T.; Thorand, B.; Thuillier, D.; Vandenput, L.; Vestergaard, H.; van Vliet-Ostaptchouk, J.V.; Vohl, M.C.; Völker, U.; Waeber, G.; Walker, M.; Wild, S.; Wong, A.; Wright, A.F.; Zillikens, M.C.; Zubair, N.; Haiman, C.A.; Lemarchand, L.; Gyllensten, U.; Ohlsson, C.; Hofman, A.; Rivadeneira, F.; Uitterlinden, A.G.; Pérusse, L.; Wilson, J.F.; Hayward, C.; Polasek, O.; Cucca, F.; Hveem, K.; Hartman, C.A.; Tönjes, A.; Bandinelli, S.; Palmer, L.J.; Kardia, SLR; Rauramaa, R.; Sørensen, TIA; Tuomilehto, J.; Salomaa, V.; Penninx, BWJH; de Geus, EJC; Boomsma, D.I.; Lehtimäki, T.; Mangino, M.; Laakso, M.; Bouchard, C.; Martin, N.G.; Kuh, D.; Liu, Y.; Linneberg, A.; März, W.; Strauch, K.; Kivimäki, M.; Harris, T.B.; Gudnason, V.; Völzke, H.; Qi, L.; Järvelin, M.R.; Chambers, J.C.; Kooner, J.S.; Froguel, P.; Kooperberg, C.; Vollenweider, P.; Hallmans, G.; Hansen, T.; Pedersen, O.; Metspalu, A.; Wareham, N.J.; Langenberg, C.; Weir, D.R.; Porteous, D.J.; Boerwinkle, E.; Chasman, D.I.; Abecasis, G.R.; Barroso, I.; McCarthy, M.I.; Frayling, T.M.; O'Connell, J.R.; van Duijn, C.M.; Boehnke, M.; Heid, I.M.; Mohlke, K.L.; Strachan, D.P.; Fox, C.S.; Liu, C.T.; Hirschhorn, J.N.; Klein, R.J.; Johnson, A.D.; Borecki, I.B.; Franks, P.W.; North, K.E.; Cupples, L.A.; Loos, RJF; Kilpeläinen, T.O.

doi:10.1371/journal.pgen.1006528

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Details

Download: BIB_C0CBE3B529A2.pdf (2590.18 [Ko])
State: Public
Version: Final published version

Serval ID

serval:BIB_C0CBE3B529A2

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

Journal

PLoS genetics

Author(s)

Graff M., Scott R.A., Justice A.E., Young K.L., Feitosa M.F., Barata L., Winkler T.W., Chu A.Y., Mahajan A., Hadley D., Xue L., Workalemahu T., Heard-Costa N.L., den Hoed M., Ahluwalia T.S., Qi Q., Ngwa J.S., Renström F., Quaye L., Eicher J.D., Hayes J.E., Cornelis M., Kutalik Z., Lim E., Luan J., Huffman J.E., Zhang W., Zhao W., Griffin P.J., Haller T., Ahmad S., Marques-Vidal P.M., Bien S., Yengo L., Teumer A., Smith A.V., Kumari M., Harder M.N., Justesen J.M., Kleber M.E., Hollensted M., Lohman K., Rivera N.V., Whitfield J.B., Zhao J.H., Stringham H.M., Lyytikäinen L.P., Huppertz C., Willemsen G., Peyrot W.J., Wu Y., Kristiansson K., Demirkan A., Fornage M., Hassinen M., Bielak L.F., Cadby G., Tanaka T., Mägi R., van der Most P.J., Jackson A.U., Bragg-Gresham J.L., Vitart V., Marten J., Navarro P., Bellis C., Pasko D., Johansson Å., Snitker S., Cheng Y.C., Eriksson J., Lim U., Aadahl M., Adair L.S., Amin N., Balkau B., Auvinen J., Beilby J., Bergman R.N., Bergmann S., Bertoni A.G., Blangero J., Bonnefond A., Bonnycastle L.L., Borja J.B., Brage S., Busonero F., Buyske S., Campbell H., Chines P.S., Collins F.S., Corre T., Smith G.D., Delgado G.E., Dueker N., Dörr M., Ebeling T., Eiriksdottir G., Esko T., Faul J.D., Fu M., Færch K., Gieger C., Gläser S., Gong J., Gordon-Larsen P., Grallert H., Grammer T.B., Grarup N., van Grootheest G., Harald K., Hastie N.D., Havulinna A.S., Hernandez D., Hindorff L., Hocking L.J., Holmens O.L., Holzapfel C., Hottenga J.J., Huang J., Huang T., Hui J., Huth C., Hutri-Kähönen N., James A.L., Jansson J.O., Jhun M.A., Juonala M., Kinnunen L., Koistinen H.A., Kolcic I., Komulainen P., Kuusisto J., Kvaløy K., Kähönen M., Lakka T.A., Launer L.J., Lehne B., Lindgren C.M., Lorentzon M., Luben R., Marre M., Milaneschi Y., Monda K.L., Montgomery G.W., De Moor MHM, Mulas A., Müller-Nurasyid M., Musk A.W., Männikkö R., Männistö S., Narisu N., Nauck M., Nettleton J.A., Nolte I.M., Oldehinkel A.J., Olden M., Ong K.K., Padmanabhan S., Paternoster L., Perez J., Perola M., Peters A., Peters U., Peyser P.A., Prokopenko I., Puolijoki H., Raitakari O.T., Rankinen T., Rasmussen-Torvik L.J., Rawal R., Ridker P.M., Rose L.M., Rudan I., Sarti C., Sarzynski M.A., Savonen K., Scott W.R., Sanna S., Shuldiner A.R., Sidney S., Silbernagel G., Smith B.H., Smith J.A., Snieder H., Stančáková A., Sternfeld B., Swift A.J., Tammelin T., Tan S.T., Thorand B., Thuillier D., Vandenput L., Vestergaard H., van Vliet-Ostaptchouk J.V., Vohl M.C., Völker U., Waeber G., Walker M., Wild S., Wong A., Wright A.F., Zillikens M.C., Zubair N., Haiman C.A., Lemarchand L., Gyllensten U., Ohlsson C., Hofman A., Rivadeneira F., Uitterlinden A.G., Pérusse L., Wilson J.F., Hayward C., Polasek O., Cucca F., Hveem K., Hartman C.A., Tönjes A., Bandinelli S., Palmer L.J., Kardia SLR, Rauramaa R., Sørensen TIA, Tuomilehto J., Salomaa V., Penninx BWJH, de Geus EJC, Boomsma D.I., Lehtimäki T., Mangino M., Laakso M., Bouchard C., Martin N.G., Kuh D., Liu Y., Linneberg A., März W., Strauch K., Kivimäki M., Harris T.B., Gudnason V., Völzke H., Qi L., Järvelin M.R., Chambers J.C., Kooner J.S., Froguel P., Kooperberg C., Vollenweider P., Hallmans G., Hansen T., Pedersen O., Metspalu A., Wareham N.J., Langenberg C., Weir D.R., Porteous D.J., Boerwinkle E., Chasman D.I., Abecasis G.R., Barroso I., McCarthy M.I., Frayling T.M., O'Connell J.R., van Duijn C.M., Boehnke M., Heid I.M., Mohlke K.L., Strachan D.P., Fox C.S., Liu C.T., Hirschhorn J.N., Klein R.J., Johnson A.D., Borecki I.B., Franks P.W., North K.E., Cupples L.A., Loos RJF, Kilpeläinen T.O.

Working group(s)

CHARGE Consortium, EPIC-InterAct Consortium, PAGE Consortium

ISSN

1553-7404 (Electronic)

ISSN-L

1553-7390

Publication state

Published

Issued date

04/2017

Peer-reviewed

Oui

Volume

Number

Pages

e1006528

Language

english

Notes

Publication types: Journal Article
Publication Status: epublish

Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

URN

urn:nbn:ch:serval-BIB_C0CBE3B529A29

OAI-PMH

oai:serval.unil.ch:BIB_C0CBE3B529A2

DOI

10.1371/journal.pgen.1006528

Pubmed

28448500

Web of science

000402549200002

Open Access

Yes