FDG-PET as a prognostic factor in high-grade astrocytoma.

Details

Serval ID
serval:BIB_C0A01119D32E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
FDG-PET as a prognostic factor in high-grade astrocytoma.
Journal
Journal of Neuro-Oncology
Author(s)
De Witte O., Lefranc F., Levivier M., Salmon I., Brotchi J., Goldman S.
ISSN
0167-594X (Print)
ISSN-L
0167-594X
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
49
Number
2
Pages
157-163
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
BACKGROUND: The prognostic value of the metabolic status of cerebral gliomas determined by positron emission tomography with [18F]-fluoro-deoxy-D-glucose (FDG-PET) has been established in populations with a mixture of grades 2, 3 and 4 gliomas, but remains uncertain when only malignant gliomas are considered (grade 3 and 4).
METHODS: FDG-PET performed in 30 patients with anaplastic astrocytoma (grade III) and 61 patients with glioblastoma (grade 4) were classified according to a metabolic grading. The uptake of FDG was lower in the tumor compared to white matter (WM) in grade 1 (4 glioblastoma, 4 anaplastic astrocytoma), it was intermediate between WM and cortex in grade 2 (20 glioblastoma, 22 anaplastic astrocytoma), and it was superior to cortex in grade 3 (38 glioblastoma, 4 anaplastic astrocytoma).
RESULTS: Kaplan-Meier survival curves were similar in patient with grades 1 and 2, but were significantly worse (p = 0.007) in grade 3. In multivariate analysis considering age, pathological grade (anaplastic astrocytoma versus glioblastoma), and metabolic grades, the metabolic grade did not appear to be an independent prognostic factor. When anaplastic astrocytomas and glioblastomas were considered separately, metabolic grade is of predictive value only in the group of glioblastomas.
CONCLUSION: In malignant gliomas, metabolic grading determined by FDG-PET was not superior to the pathological grading for survival prediction. Still, it remains of predictive value when applied to malignant gliomas histologically classified as glioblastoma.
Keywords
Adolescent, Adult, Aged, Aged, 80 and over, Brain Neoplasms/mortality, Brain Neoplasms/radiography, Fluorodeoxyglucose F18/diagnostic use, Glioblastoma/mortality, Glioblastoma/radiography, Humans, Middle Aged, Neoplasm Staging, Prognosis, Radiopharmaceuticals/diagnostic use, Survival Rate, Tomography, Emission-Computed/methods
Pubmed
Web of science
Create date
20/01/2008 18:35
Last modification date
20/08/2019 16:35
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