Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_C08EB9614B49
Type
Article: article from journal or magazin.
Collection
Publications
Title
Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders.
Journal
Translational psychiatry
Author(s)
Xiao X., Wang L., Wang C., Yuan T.F., Zhou D., Zheng F., Li L., Grigoroiu-Serbanescu M., Ikeda M., Iwata N., Takahashi A., Kamatani Y., Kubo M., Preisig M., Kutalik Z., Castelao E., Pistis G., Amin N., van Duijn C.M., Forstner A.J., Strohmaier J., Hecker J., Schulze T.G., Müller-Myhsok B., Reif A., Mitchell P.B., Martin N.G., Schofield P.R., Cichon S., Nöthen M.M., Chang H., Luo X.J., Fang Y., Yao Y.G., Zhang C., Rietschel M., Li M.
Working group(s)
Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Publication state
Published
Issued date
11/12/2017
Peer-reviewed
Oui
Volume
7
Number
12
Pages
1273
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Bipolar disorder (BPD) and major depressive disorder (MDD) are primary major mood disorders. Recent studies suggest that they share certain psychopathological features and common risk genes, but unraveling the full genetic architecture underlying the risk of major mood disorders remains an important scientific task. The public genome-wide association study (GWAS) data sets offer the opportunity to examine this topic by utilizing large amounts of combined genetic data, which should ultimately allow a better understanding of the onset and development of these illnesses. Genome-wide meta-analysis was performed by combining two GWAS data sets on BPD and MDD (19,637 cases and 18,083 controls), followed by replication analyses for the loci of interest in independent 12,364 cases and 76,633 controls from additional samples that were not included in the two GWAS data sets. The single-nucleotide polymorphism (SNP) rs10791889 at 11q13.2 was significant in both discovery and replication samples. When combining all samples, this SNP and multiple other SNPs at 2q11.2 (rs717454), 8q21.3 (rs10103191), and 11q13.2 (rs2167457) exhibited genome-wide significant association with major mood disorders. The SNPs in 2q11.2 and 8q21.3 were novel risk SNPs that were not previously reported, and SNPs at 11q13.2 were in high LD with potential BPD risk SNPs implicated in a previous GWAS. The genome-wide significant loci at 2q11.2 and 11q13.2 exhibited strong effects on the mRNA expression of certain nearby genes in cerebellum. In conclusion, we have identified several novel loci associated with major mood disorders, adding further support for shared genetic risk between BPD and MDD. Our study highlights the necessity and importance of mining public data sets to explore risk genes for complex diseases such as mood disorders.
Keywords
Bipolar Disorder/genetics, Depressive Disorder, Major/genetics, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Mood Disorders/genetics, Polymorphism, Single Nucleotide
Pubmed
Web of science
Open Access
Yes
Create date
14/12/2017 17:43
Last modification date
20/08/2019 15:35
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