Delivery systems and adjuvants for vaccination against HIV

Details

Serval ID
serval:BIB_C0707493C4EF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Delivery systems and adjuvants for vaccination against HIV
Journal
EXS
Author(s)
Velin  D., Kraehenbuhl  J. P.
ISSN
1023-294X (Print)
Publication state
Published
Issued date
2000
Volume
89
Pages
227-37
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Abstract
Epidemiological studies have revealed that HIV-1 infections occur through contact with contaminated blood or during unprotected vaginal or anal intercourse. Hence, to protect against HIV infection, vaccines should ideally induce both mucosal and systemic immune responses. We present a brief review of the different delivery systems and adjuvants which can be used to elicit mucosal immune responses. Oral or nasal administration of recombinant attenuated bacteria or viruses can induce both mucosal and systemic immune responses against the carried antigen. The oral delivery of mucosal adjuvants (such as cholera toxin) in association with antigens has been shown to enhance mucosal and systemic immune responses against them. Recently developed vaccination strategies using naked DNA or other antigen delivery systems are also discussed.
Keywords
AIDS Vaccines/*administration & dosage Adjuvants, Immunologic/administration & dosage Animals CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Drug Delivery Systems Female HIV Antibodies/metabolism HIV Infections/immunology/*prevention & control Humans Immunity, Mucosal Male Neutralization Tests Vaccines, DNA/administration & dosage Vaccines, Synthetic/administration & dosage
Pubmed
Create date
25/01/2008 16:10
Last modification date
20/08/2019 15:34
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