B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_C05812F2D567
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
B cell-T cell interplay in immune regulation: A focus on follicular regulatory T and regulatory B cell functions.
Journal
Frontiers in cell and developmental biology
Author(s)
Tan D., Yin W., Guan F., Zeng W., Lee P., Candotti F., James L.K., Saraiva Camara N.O., Haeryfar SMM, Chen Y., Benlagha K., Shi L.Z., Lei J., Gong Q., Liu Z., Liu C.
ISSN
2296-634X (Print)
ISSN-L
2296-634X
Publication state
Published
Issued date
2022
Peer-reviewed
Oui
Volume
10
Pages
991840
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions. Forkhead box P3 (FoxP3)-expressing regulatory T cells (Tregs) are key players in sustaining immune tolerance and keeping inflammation in check. Mounting evidence suggests complex communications between B cells and Tregs. In this review, we summarize the yin-yang regulatory relationships between B cells and Tregs mainly from the perspectives of T follicular regulatory (Tfr) cells and regulatory B cells (Bregs). We discuss the regulatory effects of Tfr cells on B cell proliferation and the germinal center response. Additionally, we review the indispensable role of B cells in ensuring homeostatic Treg survival and describe the function of Bregs in promoting Treg responses. Finally, we introduce a new subset of Tregs, termed Treg-of-B cells, which are induced by B cells, lake the expression of FoxP3 but still own immunomodulatory effects. In this article, we also enumerate a sequence of research from clinical patients and experimental models to clarify the role of Tfr cells in germinal centers and the role of convention B cells and Bregs to Tregs in the context of different diseases. This review offers an updated overview of immunoregulatory networks and unveils potential targets for therapeutic interventions against cancer, autoimmune diseases and allograft rejection.
Keywords
B cells, T follicular regulatory cells, germinal center, humoral responses, regulatory B cells (bregs), regulatory T cells, treg-of-B cells
Pubmed
Web of science
Open Access
Yes
Create date
18/10/2022 7:26
Last modification date
23/01/2024 7:33
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