Antifungal tests in phytochemical investigations: comparison of bioautographic methods using phytopathogenic and human pathogenic fungi

Details

Serval ID
serval:BIB_BFDC40B34FC2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Antifungal tests in phytochemical investigations: comparison of bioautographic methods using phytopathogenic and human pathogenic fungi
Journal
Planta Medica
Author(s)
Rahalison  L., Hamburger  M., Monod  M., Frenk  E., Hostettmann  K.
ISSN
0032-0943 (Print)
Publication state
Published
Issued date
02/1994
Volume
60
Number
1
Pages
41-4
Notes
Journal Article --- Old month value: Feb
Abstract
The detection limits in two bioautographic assays have been determined for a series of antifungal compounds, including clinically used antimycotics, fungicidal agrochemicals, and various classes of secondary plant metabolites. Target organisms were the filamentous fungus Cladosporium cucumerinum and the yeast Candida albicans. For clinical agents and agrochemicals, the detection limits in the two assays reflected to a certain extent their known spectrum of activity. Most of the plant-derived compounds tested showed a positive response in both assays, but with detection limits varying by a factor up to tenfold. For screening purposes, it is thus advisable to use both tests, as some activities would otherwise go undetected. The MIC values of these substances were determined in order to verify a possible correlation with the detection limit in the bioautographic assays.
Keywords
Antifungal Agents/*pharmacology Candida albicans/*drug effects Cladosporium/*drug effects Fungicides, Industrial/pharmacology Humans Microbial Sensitivity Tests/*methods Plant Extracts/*pharmacology Plants/microbiology
Pubmed
Web of science
Create date
25/01/2008 17:46
Last modification date
20/08/2019 16:34
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