Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marché Hospital, Bunia, Democratic Republic of the Congo.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_BFCBF634CD4E
Type
Article: article from journal or magazin.
Collection
Publications
Title
Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marché Hospital, Bunia, Democratic Republic of the Congo.
Journal
Tropical medicine & international health : TM & IH
Author(s)
Mueller Y., Bastard M., Ehounou G., Itama J., Quéré M., de la Tour R., Vala L., Etard J.F., Bottineau M.C.
ISSN
1365-3156 (Electronic)
ISSN-L
1360-2276
Publication state
Published
Issued date
12/2012
Peer-reviewed
Oui
Volume
17
Number
12
Pages
1457-1464
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
To assess the effectiveness of blood transfusions in a hospital of north-eastern Democratic Republic of the Congo.
Prospective study of children admitted for severe anaemia. During admission, data were collected on clinical condition and haemoglobin levels, before and after blood transfusion. A linear regression model was built to explore factors associated with haemoglobin level after transfusion. Risk factors for mortality were explored through multivariate logistic regression.
Haemoglobin level (Hb) was below 4 g/dl in 35% (230/657), between 4 and 6 g/dl in 58% (348/657) and at least 6 g/dl in another 6% (43/657) of the transfused children. A transfusion of 15 ml/kg of whole blood increased the Hb from 4.4 to 7.8 g/dl. Haemoglobin level after transfusion was associated with baseline Hb, quantity of delivered blood and history of previous transfusions. Overall case-fatality rate was 5.6% (37/657). Risk factors for deaths were co-morbidities such as chest infection, meningitis or malnutrition, Hb ≥ 6 g/dl, impaired consciousness or jugular venous distention on admission, and provenance.
Transfusion was a frequent practice, the use of which could clearly have been rationalised. While indications should be restricted, quantities of transfused blood should be adapted to needs.

Keywords
Anemia/mortality, Anemia/therapy, Blood Transfusion/adverse effects, Child, Preschool, Comorbidity, Democratic Republic of the Congo/epidemiology, Female, Hemoglobins/metabolism, Hospital Mortality, Humans, Infant, Linear Models, Logistic Models, Male, Multivariate Analysis, Prospective Studies, Risk Factors
Pubmed
Open Access
Yes
Create date
23/02/2016 19:14
Last modification date
20/08/2019 16:34
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