Combining bone resorption markers and heel quantitative ultrasound to discriminate between fracture cases and controls.

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It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_BF3A9C15FC05
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Combining bone resorption markers and heel quantitative ultrasound to discriminate between fracture cases and controls.
Journal
Osteoporosis International
Author(s)
Nanchen D., Cornuz J., Ruffieux C., Riesen W., Burckhardt P., Krieg M.A.
ISSN
1433-2965[electronic]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
20
Number
10
Pages
1695-1703
Language
english
Abstract
This nested case-control analysis of a Swiss ambulatory cohort of elderly women assessed the discriminatory power of urinary markers of bone resorption and heel quantitative ultrasound for non-vertebral fractures. The tests all discriminated between cases and controls, but combining the two strategies yielded no additional relevant information. INTRODUCTION: Data are limited regarding the combination of bone resorption markers and heel quantitative bone ultrasound (QUS) in the detection of women at risk for fracture. METHODS: In a nested case-control analysis, we studied 368 women (mean age 76.2 +/- 3.2 years), 195 with low-trauma non-vertebral fractures and 173 without, matched for age, BMI, medical center, and follow-up duration, from a prospective study designed to predict fractures. Urinary total pyridinolines (PYD) and deoxypyridinolines (DPD) were measured by high performance liquid chromatography. All women underwent bone evaluations using Achilles+ and Sahara heel QUS. RESULTS: Areas under the receiver operating-characteristic curve (AUC) for discriminative models of the fracture group, with 95% confidence intervals, were 0.62 (0.56-0.68) and 0.59 (0.53-0.65) for PYD and DPD, and 0.64 (0.58-0.69) and 0.65 (0.59-0.71) for Achilles+ and Sahara QUS, respectively. The combination of resorption markers and QUS added no significant discriminatory information to either measurement alone with an AUC of 0.66 (0.60-0.71) for Achilles+ with PYD and 0.68 (0.62-0.73) for Sahara with PYD. CONCLUSIONS: Urinary bone resorption markers and QUS are equally discriminatory between non-vertebral fracture patients and controls. However, the combination of bone resorption markers and QUS is not better than either test used alone.
Pubmed
Web of science
Open Access
Yes
Create date
24/06/2009 16:33
Last modification date
01/10/2019 7:19
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