Genome-wide association study identifies eight loci associated with blood pressure.

Newton-Cheh, C.; Johnson, T.; Gateva, V.; Tobin, M.D.; Bochud, M.; Coin, L.; Najjar, S.S.; Zhao, J.H.; Heath, S.C.; Eyheramendy, S.; Papadakis, K.; Voight, B.F.; Scott, L.J.; Zhang, F.; Farrall, M.; Tanaka, T.; Wallace, C.; Chambers, J.C.; Khaw, K.T.; Nilsson, P.; van der Harst, P.; Polidoro, S.; Grobbee, D.E.; Onland-Moret, N.C.; Bots, M.L.; Wain, L.V.; Elliott, K.S.; Teumer, A.; Luan, J.; Lucas, G.; Kuusisto, J.; Burton, P.R.; Hadley, D.; McArdle, W.L.; Brown, M.; Brown, M.; Dominiczak, A.; Newhouse, S.J.; Samani, N.J.; Webster, J.; Zeggini, E.; Beckmann, J.S.; Bergmann, S.; Lim, N.; Song, K.; Vollenweider, P.; Waeber, G.; Waterworth, D.M.; Yuan, X.; Groop, L.; Orho-Melander, M.; Allione, A.; Di Gregorio, A.; Guarrera, S.; Panico, S.; Ricceri, F.; Romanazzi, V.; Sacerdote, C.; Vineis, P.; Barroso, I.; Sandhu, M.S.; Luben, R.N.; Crawford, G.J.; Jousilahti, P.; Perola, M.; Boehnke, M.; Bonnycastle, L.L.; Collins, F.S.; Jackson, A.U.; Mohlke, K.L.; Stringham, H.M.; Valle, T.T.; Willer, C.J.; Bergman, R.N.; Morken, M.A.; Döring, A.; Gieger, C.; Illig, T.; Meitinger, T.; Org, E.; Pfeufer, A.; Wichmann, H.E.; Kathiresan, S.; Marrugat, J.; O'Donnell, C.J.; Schwartz, S.M.; Siscovick, D.S.; Subirana, I.; Freimer, N.B.; Hartikainen, A.L.; McCarthy, M.I.; O'Reilly, P.F.; Peltonen, L.; Pouta, A.; de Jong, P.E.; Snieder, H.; van Gilst, W.H.; Clarke, R.; Goel, A.; Hamsten, A.; Peden, J.F.; Seedorf, U.; Syvänen, A.C.; Tognoni, G.; Lakatta, E.G.; Sanna, S.; Scheet, P.; Schlessinger, D.; Scuteri, A.; Dörr, M.; Ernst, F.; Felix, S.B.; Homuth, G.; Lorbeer, R.; Reffelmann, T.; Rettig, R.; Völker, U.; Galan, P.; Gut, I.G.; Hercberg, S.; Lathrop, G.M.; Zelenika, D.; Deloukas, P.; Soranzo, N.; Williams, F.M.; Zhai, G.; Salomaa, V.; Laakso, M.; Elosua, R.; Forouhi, N.G.; Völzke, H.; Uiterwaal, C.S.; van der Schouw, Y.T.; Numans, M.E.; Matullo, G.; Navis, G.; Berglund, G.; Bingham, S.A.; Kooner, J.S.; Connell, J.M.; Bandinelli, S.; Ferrucci, L.; Watkins, H.; Spector, T.D.; Tuomilehto, J.; Altshuler, D.; Strachan, D.P.; Laan, M.; Meneton, P.; Wareham, N.J.; Uda, M.; Jarvelin, M.R.; Mooser, V.; Melander, O.; Loos, R.J.; Elliott, P.; Abecasis, G.R.; Caulfield, M.; Munroe, P.B.

doi:10.1038/ng.361

Genome-wide association study identifies eight loci associated with blood pressure.

Details

Download: 19430483_BIB_BF347FE89719.pdf (1100.23 [Ko])
State: Public
Version: Author's accepted manuscript
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Serval ID

serval:BIB_BF347FE89719

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Genome-wide association study identifies eight loci associated with blood pressure.

Journal

Nature Genetics

Author(s)

Newton-Cheh C., Johnson T., Gateva V., Tobin M.D., Bochud M., Coin L., Najjar S.S., Zhao J.H., Heath S.C., Eyheramendy S., Papadakis K., Voight B.F., Scott L.J., Zhang F., Farrall M., Tanaka T., Wallace C., Chambers J.C., Khaw K.T., Nilsson P., van der Harst P., Polidoro S., Grobbee D.E., Onland-Moret N.C., Bots M.L., Wain L.V., Elliott K.S., Teumer A., Luan J., Lucas G., Kuusisto J., Burton P.R., Hadley D., McArdle W.L., Brown M., Brown M., Dominiczak A., Newhouse S.J., Samani N.J., Webster J., Zeggini E., Beckmann J.S., Bergmann S., Lim N., Song K., Vollenweider P., Waeber G., Waterworth D.M., Yuan X., Groop L., Orho-Melander M., Allione A., Di Gregorio A., Guarrera S., Panico S., Ricceri F., Romanazzi V., Sacerdote C., Vineis P., Barroso I., Sandhu M.S., Luben R.N., Crawford G.J., Jousilahti P., Perola M., Boehnke M., Bonnycastle L.L., Collins F.S., Jackson A.U., Mohlke K.L., Stringham H.M., Valle T.T., Willer C.J., Bergman R.N., Morken M.A., Döring A., Gieger C., Illig T., Meitinger T., Org E., Pfeufer A., Wichmann H.E., Kathiresan S., Marrugat J., O'Donnell C.J., Schwartz S.M., Siscovick D.S., Subirana I., Freimer N.B., Hartikainen A.L., McCarthy M.I., O'Reilly P.F., Peltonen L., Pouta A., de Jong P.E., Snieder H., van Gilst W.H., Clarke R., Goel A., Hamsten A., Peden J.F., Seedorf U., Syvänen A.C., Tognoni G., Lakatta E.G., Sanna S., Scheet P., Schlessinger D., Scuteri A., Dörr M., Ernst F., Felix S.B., Homuth G., Lorbeer R., Reffelmann T., Rettig R., Völker U., Galan P., Gut I.G., Hercberg S., Lathrop G.M., Zelenika D., Deloukas P., Soranzo N., Williams F.M., Zhai G., Salomaa V., Laakso M., Elosua R., Forouhi N.G., Völzke H., Uiterwaal C.S., van der Schouw Y.T., Numans M.E., Matullo G., Navis G., Berglund G., Bingham S.A., Kooner J.S., Connell J.M., Bandinelli S., Ferrucci L., Watkins H., Spector T.D., Tuomilehto J., Altshuler D., Strachan D.P., Laan M., Meneton P., Wareham N.J., Uda M., Jarvelin M.R., Mooser V., Melander O., Loos R.J., Elliott P., Abecasis G.R., Caulfield M., Munroe P.B.

Working group(s)

Wellcome Trust Case Control Consortium

Contributor(s)

Burton PR., Clayton DG., Cardon LR., Craddock N., Deloukas P., Duncanson A., Kwiatkowski DP., McCarthy MI., Ouwehand WH., Samani NJ., Todd JA., Donnelly P., Barrett JC., Burton PR., Davison D., Donnelly P., Easton D., Evans D., Leung HT., Marchini JL., Morris AP., Spencer IC., Tobin MD., Cardon LR., Clayton DG., Attwood AP., Boorman JP., Cant B., Everson U., Hussey JM., Jolley JD., Knight AS., Koch K., Meech E., Nutland S., Prowse CV., Stevens HE., Taylor NC., Walters GR., Walker NM., Watkins NA., Winzer T., Todd JA., Ouwehand WH., Jones RW., McArdle WL., Ring SM., Strachan DP., Pembrey M., Breen G., St Clair D., Caesar S., Gordon-Smith K., Jones L., Fraser C., Green EK., Grozeva D., Hamshere ML., Holmans PA., Jones IR., Kirov G., Moskvina V., Nikolov I., O'Donovan MC., Owen MJ., Craddock N., Collier DA., Elkin A., Farmer A., Williamson R., McGuffin P., Young AH., Ferrier IN., Ball SG., Balmforth AJ., Barrett JH., Bishop DT., Iles MM., Maqbool A., Yuldasheva N., Hall AS., Braund PS., Burton PR., Dixon RJ., Mangino M., Stevens S., Tobin MD., Thompson JR., Samani NJ., Bredin F., Tremelling M., Parkes M., Drummond H., Lees CW., Nimmo ER., Satsangi J., Fisher SA., Forbes A., Lewis CM., Onnie CM., Prescott NJ., Sanderson J., Mathew CG., Barbour J., Mohiuddin MK., Todhunter CE., Mansfield JC., Ahmad T., Cummings FR., Jewell DP., Webster J., Brown MJ., Clayton DG., Lathrop GM., Connell J., Dominiczak A., Samani NJ., Braga Marcano CA., Burke B., Dobson R., Gungadoo J., Lee KL., Munroe PB., Newhouse SJ., Onipinla A., Wallace I., Xue M., Caulfield M., Farrall M., Barton A., Bruce IN., Donovan H., Eyre S., Gilbert PD., Hider SL., Hinks AM., John SL., Potter C., Silman AJ., Symmons DP., Thomson W., Worthington J., Clayton DG., Dunger DB., Nutland S., Stevens HE., Walker NM., Widmer B., Todd JA., Frayling TM., Freathy RM., Lango H., Perry JR., Shields BM., Weedon MN., Hattersley AT., Hitman GA., Walker M., Elliott KS., Groves CJ., Lindgren CM., Rayner NW., Timpson NJ., Zeggini E., McCarthy MI., Newport M., Sirugo G., Lyons E., Vannberg F., Hill AV., Bradbury LA., Farrar C., Pointon JJ., Wordsworth P., Brown MA., Franklyn JA., Heward JM., Simmonds MJ., Gough SC., Seal S., Stratton MR., Rahman N., Ban M., Goris A., Sawcer SJ., Compston A., Conway D., Jallow M., Newport M., Sirugo G., Rockett KA., Kwiatkowski DP., Bryan C., Bumpstead SJ., Chaney A., Downes K., Ghori J., Gwilliam R., Hunt SE., Inouye M., Keniry A., King E., McGinnis R., Potter S., Ravindrarajah R., Whittaker P., Withers D., Deloukas P., Leung HT., Nutland S., Stevens HE., Walker NM., Todd JA., Easton D., Clayton DG., Burton PR., Tobin MD., Barrett JC., Evans D., Morris AP., Cardon LR., Cardin NJ., Davison D., Ferreira T., Pereira-Gale J., Hallgrimsdóttir IB., Howie BN., Marchini JL., Spencer IC., Su Z., Teo YY., Vukcevic D., Donnelly P., Bentley D., Brown MA., Cardon LR., Caulfield M., Clayton DG., Compston A., Craddock N., Deloukas P., Donnelly P., Farrall M., Gough SC., Hall AS., Hattersley AT., Hill AV., Kwiatkowski DP., Mathew CG., McCarthy MI., Ouwehand WH., Parkes M., Pembrey M., Rahman N., Samani NJ., Stratton MR., Todd JA., Worthington J.

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

2009

Peer-reviewed

Oui

Volume

Number

Pages

666-676

Language

english

Notes

Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

Keywords

Blood Pressure/genetics, Cardiovascular Diseases/genetics, Cardiovascular Diseases/physiopathology, Chromosome Mapping, Cytochrome P-450 CYP1A2/genetics, DNA-Binding Proteins/genetics, Diastole/genetics, Europe, European Continental Ancestry Group/genetics, Fibroblast Growth Factor 5/genetics, Genetic Variation, Genome-Wide Association Study, Humans, India, Methylenetetrahydrofolate Reductase (NADPH2)/genetics, Open Reading Frames/genetics, Phospholipase C delta/genetics, Polymorphism, Single Nucleotide, Proteins/genetics, Steroid 17-alpha-Hydroxylase/genetics, Systole/genetics

URN

urn:nbn:ch:serval-BIB_BF347FE897190

OAI-PMH

oai:serval.unil.ch:BIB_BF347FE89719

DOI

10.1038/ng.361

Pubmed

19430483

Web of science

000266411700015

Create date

05/06/2009 6:23