Maladie de Forestier et troubles du métabolisme. Etude prospective contrôlée de vingt-cinq cas [Forestier disease and metabolism disorders. A prospective controlled study of 25 cases].

Details

Serval ID
serval:BIB_BF1E1E885521
Type
Article: article from journal or magazin.
Collection
Publications
Title
Maladie de Forestier et troubles du métabolisme. Etude prospective contrôlée de vingt-cinq cas [Forestier disease and metabolism disorders. A prospective controlled study of 25 cases].
Journal
Revue du Rhumatisme
Author(s)
Troillet N., Gerster J.C.
ISSN
1169-8330 (Print)
ISSN-L
1169-8330
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
60
Number
4
Pages
274-279
Language
french
Notes
Publication types: Clinical Trial ; Comparative Study ; English Abstract ; Journal Article ; Randomized Controlled Trial
Abstract
Metabolic disorders including diabetes mellitus, glucose intolerance, dyslipidemias, hyperuricemia, and hypervitaminosis A have often been mentioned in association with diffuse idiopathic skeletal hyperostosis (DISH). Production of bone under the influence of insulin or retinol has been suggested as a possible mechanism for this disease. We prospectively studied metabolic disorders in 25 patients with DISH and 25 controls matched for age, sex, and body mass index. Correlations between simultaneously evaluated parameters were looked for. Obesity was prevalent in both groups. Serum levels of glucose, insulin, glycated hemoglobin, total cholesterol, HDL cholesterol, triglycerides, uric acid, retinol, and retinol binding protein were similar in the two groups. A positive correlation was found between body mass index and serum insulin. We found no correlation between serum levels of insulin and retinol. None of the metabolic parameters studied showed alterations likely to explain the development of hyperostosis. Other growth factors such as retinoic acid or insulin-like growth factor 1, perhaps produced on a paracrine basis, may be the cause of increased bone at enthesis production.
Keywords
Adult, Aged, Body Mass Index, Case-Control Studies, Diabetes Mellitus, Type 2/complications, Female, Humans, Hyperostosis, Diffuse Idiopathic Skeletal/epidemiology, Hyperostosis, Diffuse Idiopathic Skeletal/etiology, Hypervitaminosis A/complications, Insulin/blood, Insulin Resistance, Male, Metabolic Diseases/complications, Middle Aged, Obesity/complications, Prospective Studies, Uric Acid/blood, Vitamin A/blood
Pubmed
Create date
28/12/2013 19:00
Last modification date
20/08/2019 16:33
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