Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy.

Details

Serval ID
serval:BIB_BEF17EF87EE2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy.
Journal
Cancers
Author(s)
Le Reun E., Granzotto A., Pêtre A., Bodgi L., Beldjoudi G., Lacornerie T., Vallet V., Bouchet A., Al-Choboq J., Bourguignon M., Thariat J., Bourhis J., Lartigau E., Foray N.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
05/08/2023
Peer-reviewed
Oui
Volume
15
Number
15
Pages
3979
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Stereotactic body radiation therapy (SBRT) has made the hypofractionation of high doses delivered in a few sessions more acceptable. While the benefits of hypofractionated SBRT have been attributed to additional vascular, immune effects, or specific cell deaths, a radiobiological and mechanistic model is still needed. By considering each session of SBRT, the dose is divided into hundreds of minibeams delivering some fractions of Gy. In such a dose range, the hypersensitivity to low dose (HRS) phenomenon can occur. HRS produces a biological effect equivalent to that produced by a dose 5-to-10 times higher. To examine whether HRS could contribute to enhancing radiation effects under SBRT conditions, we exposed tumor cells of different HRS statuses to SBRT. Four human HRS-positive and two HRS-negative tumor cell lines were exposed to different dose delivery modes: a single dose of 0.2 Gy, 2 Gy, 10 × 0.2 Gy, and a single dose of 2 Gy using a non-coplanar isocentric minibeams irradiation mode were delivered. Anti-γH2AX immunofluorescence, assessing DNA double-strand breaks (DSB), was applied. In the HRS-positive cells, the DSB produced by 10 × 0.2 Gy and 2 Gy, delivered by tens of minibeams, appeared to be more severe, and they provided more highly damaged cells than in the HRS-negative cells, suggesting that more severe DSB are induced in the "SBRT modes" conditions when HRS occurs in tumor. Each SBRT session can be viewed as hyperfractionated dose delivery by means of hundreds of low dose minibeams. Under current SBRT conditions (i.e., low dose per minibeam and not using ultra-high dose-rate), the response of HRS-positive tumors to SBRT may be enhanced significantly. Interestingly, similar conclusions were reached with HRS-positive and HRS-negative untransformed fibroblast cell lines, suggesting that the HRS phenomenon may also impact the risk of post-RT tissue overreactions.
Keywords
HRS phenomenon, Ldrt, Sbrt, cancer, low-dose, radiation therapy, radiosensitivity, LDRT, SBRT
Pubmed
Web of science
Open Access
Yes
Create date
21/08/2023 7:22
Last modification date
09/12/2023 7:03
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