Polyarteritis Nodosa: Old Disease, New Etiologies.

Details

Serval ID
serval:BIB_BEEF8077D35B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Polyarteritis Nodosa: Old Disease, New Etiologies.
Journal
International journal of molecular sciences
Author(s)
Wolff L., Horisberger A., Moi L., Karampetsou M.P., Comte D.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
23/11/2023
Peer-reviewed
Oui
Volume
24
Number
23
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
Polyarteritis nodosa (PAN), also known as panarteritis nodosa, represents a form of necrotizing vasculitis that predominantly affects medium-sized vessels, although it is not restricted to them and can also involve smaller vessels. The clinical presentation is heterogeneous and characterized by a significant number of patients exhibiting general symptoms, including asthenia, fever, and unintended weight loss. Although PAN can involve virtually any organ, it preferentially affects the skin, nervous system, and the gastrointestinal tract. Orchitis is a rare but specific manifestation of PAN. The absence of granulomas, glomerulonephritis, and anti-neutrophil cytoplasmic antibodies serves to distinguish PAN from other types of vasculitis. Major complications consist of hemorrhagic and thrombotic events occurring in mesenteric, cardiac, cerebral, and renal systems. Historically, PAN was frequently linked to hepatitis B virus (HBV) infection, but this association has dramatically changed in recent years due to declining HBV prevalence. Current epidemiological research often identifies a connection between PAN and genetic syndromes as well as neoplasia. This article provides a comprehensive review of PAN, specifically focusing on the progression of its clinical manifestations over time.
Keywords
Male, Humans, Polyarteritis Nodosa/complications, Polyarteritis Nodosa/diagnosis, Vasculitis, Hepatitis B/complications, Hepatitis B virus, Gastrointestinal Tract, DADA2, PAN, VEXAS, monogenic, panarteritis nodosa, polyarteritis nodosa
Pubmed
Web of science
Open Access
Yes
Create date
15/12/2023 14:29
Last modification date
20/01/2024 7:11
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