Platelet activation and aggregation profile in prolonged external ventricular support.

Details

Serval ID
serval:BIB_BEE4F8AAA1F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Platelet activation and aggregation profile in prolonged external ventricular support.
Journal
The Journal of thoracic and cardiovascular surgery
Author(s)
Houël R., Mazoyer E., Boval B., Kirsch M., Vermès E., Drouet L., Loisance D.Y.
ISSN
0022-5223 (Print)
ISSN-L
0022-5223
Publication state
Published
Issued date
08/2004
Peer-reviewed
Oui
Volume
128
Number
2
Pages
197-202
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Platelet function plays a major role in the understanding of thromboembolic events in prolonged mechanical support. We studied the platelet activation, platelet aggregation profile, and efficacy of aspirin in patients in whom an external ventricular assist device had been implanted.
Fifteen patients were studied prospectively up to 6 weeks after implantation of the same type of ventricular assist device. Platelet function was studied weekly before daily aspirin administration. Aspirin efficacy was tested ex vivo by measuring platelet aggregation triggered by arachidonic acid. Flow cytometry was used to quantify the spontaneous and induced (adenosine diphosphate stimulation) expression of glycoproteins alphaIIbbeta3, Ibalpha, and CD62P on platelet membranes. The plasma levels of von Willebrand factor (von Willebrand factor activity and von Willebrand factor antigen) and fibrinogen were also determined.
Six of the 15 patients (26%) maintained an arachidonic acid-induced platelet aggregation despite daily aspirin treatment (250 mg). CD62P values remained increased during a 5-week postoperative period. Spontaneous levels of glycoproteins alphaIIbbeta3 and Ibalpha on platelet membranes remained within a normal range with a preserved reactivity. The plasma levels of fibrinogen and von Willebrand factor remained increased during the entire study period.
In patients with an implanted external ventricular assist device, the platelet activation profile displays a persistent activation with a preserved reactivity associated with a persistent high inflammatory state and endothelial activation.
Keywords
Adolescent, Aspirin/therapeutic use, Female, Heart-Assist Devices, Humans, Male, Middle Aged, Platelet Activation/drug effects, Platelet Aggregation/drug effects, Platelet Aggregation Inhibitors/therapeutic use, Prospective Studies, Time Factors
Pubmed
Web of science
Open Access
Yes
Create date
30/03/2019 16:54
Last modification date
26/11/2020 6:26
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