Acute graft-versus-host disease without costimulation via CD28
Details
Serval ID
serval:BIB_BEE1F8B1A9A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acute graft-versus-host disease without costimulation via CD28
Journal
Transplantation
ISSN
0041-1337 (Print)
Publication state
Published
Issued date
04/1997
Volume
63
Number
7
Pages
1042-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr 15
Research Support, Non-U.S. Gov't --- Old month value: Apr 15
Abstract
T lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These findings prompted us to investigate the role of CD28 in acute GVHD, using gene-targeted mice. We performed the experiments in the context of strong allogeneic MHC stimulation (H2(b) anti-H2(d)) and weak stimulation (H2(d) anti-H2(b)). In both directions, efficient in vitro T-cell cytotoxicity and acute lethal GVHD were induced by CD28-deficient lymphocytes, which was only partially delayed when compared with wild-type mice. We conclude that lethal GVHD can develop without costimulation via CD28.
Keywords
Acute Disease
Animals
Antigens, CD
Antigens, CD28/*immunology
Antigens, Differentiation/therapeutic use
Crosses, Genetic
Graft vs Host Disease/*immunology/prevention & control
*Immunoconjugates
Lymphocyte Activation/immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
T-Lymphocytes/*immunology
Transplantation, Homologous
Pubmed
Web of science
Create date
28/01/2008 11:33
Last modification date
20/08/2019 15:33