Some of the early events underlying Th2 cell maturation and susceptibility to Leishmania major infection in BALB/c mice.

Details

Serval ID
serval:BIB_BEAE91E1875A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Some of the early events underlying Th2 cell maturation and susceptibility to Leishmania major infection in BALB/c mice.
Journal
Biological Chemistry
Author(s)
Himmelrich H., Launois P., Tacchini-Cottier F., Louis J.A.
ISSN
1431-6730 (Print)
ISSN-L
1431-6730
Publication state
Published
Issued date
1999
Volume
380
Number
7-8
Pages
909-914
Language
english
Abstract
The first experimental evidence for the development of polarized CD4+ Th1 and Th2 responses in vivo has been obtained using the murine model of infection with Leishmania major, an intracellular parasite of macrophages in their vertebrate host. Genetically determined resistance and susceptibility to infection with this parasite have been clearly demonstrated to result from the development of polarized Th1 and Th2 responses, respectively. Using this model system, the dominant role of cytokines in the induction of polarized CD4+ responses has been validated in vivo. The requisite role of IL-4 in mediating both Th2 differentiation and susceptibility to infection in BALB/c mice has directed interest towards the search for evidence of IL-4 production early after infection and identification of its cellular source. We have been able to demonstrate a burst of IL-4 production in susceptible BALB/c mice within the first day of infection with L. major and could establish that this rapidly produced IL-4 instructed Th2 lineage commitment of subsequently activated CD4+ T cells and stabilized this commitment by downregulating IL-12 Rbeta2 chain expression, resulting in susceptibility to infection. Strikingly, this early IL-4 response to infection resulted from the cognate recognition of a single epitope in a distinctive antigen, LACK, from this complex microorganism by a restricted population of CD4+ T cells that express Vbeta4-Valpha8 T cell receptors.
Keywords
Animals, Cytokines/biosynthesis, Cytokines/immunology, Disease Models, Animal, Leishmania major/pathogenicity, Leishmaniasis/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Th2 Cells/cytology, Th2 Cells/parasitology
Pubmed
Web of science
Create date
24/01/2008 16:08
Last modification date
20/08/2019 16:32
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