Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone.
Details
Serval ID
serval:BIB_BE86A1E7FA01
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone.
Journal
Nature immunology
ISSN
1529-2916[electronic]
Publication state
Published
Issued date
2008
Volume
9
Number
6
Pages
667-675
Language
english
Abstract
The generation of lymphoid microenvironments in early life depends on the interaction of lymphoid tissue-inducer cells with stromal lymphoid tissue-organizer cells. Whether this cellular interface stays operational in adult secondary lymphoid organs has remained elusive. We show here that during acute infection with lymphocytic choriomeningitis virus, antiviral cytotoxic T cells destroyed infected T cell zone stromal cells, which led to profound disruption of secondary lymphoid organ integrity. Furthermore, the ability of the host to respond to secondary antigens was lost. Restoration of the lymphoid microanatomy was dependent on the proliferative accumulation of lymphoid tissue-inducer cells in secondary lymphoid organs during the acute phase of infection and lymphotoxin alpha(1)beta(2) signaling. Thus, crosstalk between lymphoid tissue-inducer cells and stromal cells is reactivated in adults to maintain secondary lymphoid organ integrity and thereby contributes to the preservation of immunocompetence.
Keywords
Animals, Arenaviridae Infections, Lymphatic System, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Lymphoid Tissue, Organ Specificity, Receptors, Antigen, T-Cell, Stromal Cells, T-Lymphocytes, Cytotoxic, T-Lymphocytes, Helper-Inducer
Pubmed
Web of science
Create date
24/03/2009 16:19
Last modification date
20/08/2019 16:32