Cannabis, a Significant Risk Factor for Violent Behavior in the Early Phase Psychosis. Two Patterns of Interaction of Factors Increase the Risk of Violent Behavior: Cannabis Use Disorder and Impulsivity; Cannabis Use Disorder, Lack of Insight and Treatment Adherence.

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State: Public
Version: Final published version
Serval ID
serval:BIB_BE8350394065
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cannabis, a Significant Risk Factor for Violent Behavior in the Early Phase Psychosis. Two Patterns of Interaction of Factors Increase the Risk of Violent Behavior: Cannabis Use Disorder and Impulsivity; Cannabis Use Disorder, Lack of Insight and Treatment Adherence.
Journal
Frontiers in psychiatry
Author(s)
Moulin V., Baumann P., Gholamrezaee M., Alameda L., Palix J., Gasser J., Conus P.
ISSN
1664-0640 (Print)
ISSN-L
1664-0640
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
9
Pages
294
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
<b>Background:</b> Previous literature suggests that prevalence of cannabis use in the early phase of psychosis is high, and that early psychosis patients are at high-risk for violent behavior. However, the link between cannabis use and violent behavior in early psychosis patients is unclear. We carried out a study on a sample of early psychosis patients, in order to explore the impact of cannabis use on the risk of violent behavior (VB), while taking into account (1) potential confounding factors and, (2) interactions with other dynamic risk factors of VB. <b>Method:</b> In a sample of 265 early psychosis patients, treated at the Treatment and Early Intervention in Psychosis Program (TIPP) in Lausanne, we used logistic regression models to explore the link between various dynamic risk factors of VB [positive symptoms, substance use disorder (drugs including cannabis, alcohol and others drugs), insight, impulsivity, affective instability, and treatment adherence], and VB occurring during treatment. In order to understand hierarchical effects attributable to the combinations of risk factors on VB we conducted a Classification and Regression Tree (CART). <b>Results:</b> Our results show that cannabis use disorder is a risk factor for VB. The associations among risk factors suggest the presence of two patient profiles with an increased rate of VB: the first is composed of patients with cannabis use disorder and impulsivity, and the second of patients combining cannabis use disorder, absence of insight and non-adherence to treatment. The results also show the moderating role of insight and adherence to treatment on the rate of VB in patients with cannabis use disorder. <b>Conclusion:</b> This study suggests that cannabis use disorder is a significant risk factor for VB amongst early psychosis patients, particularly when combined with either impulsivity, lack of insight and non-adherence to treatment. These results suggest that preventive strategies could be developed on the basis of such patient profiles.
Keywords
Psychiatry and Mental health, cannabis use disorder, early phase of psychosis, impulsivity, insight, profiles, violent behavior
Pubmed
Web of science
Open Access
Yes
Create date
19/06/2018 13:32
Last modification date
20/08/2019 15:32
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