Approach to nodal-based T-cell lymphomas.

Details

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State: Public
Version: Author's accepted manuscript
License: Not specified
Serval ID
serval:BIB_BE47511FDD75
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Approach to nodal-based T-cell lymphomas.
Journal
Pathology
Author(s)
de Leval L.
ISSN
1465-3931 (Electronic)
ISSN-L
0031-3025
Publication state
Published
Issued date
01/2020
Peer-reviewed
Oui
Volume
52
Number
1
Pages
78-99
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of uncommon malignancies derived from mature T cells and usually characterised by an aggressive clinical course. Their clinical presentation, localisation and pattern of dissemination are highly variable, but the majority of cases present as nodal diseases. The recently revised classification of lymphomas has incorporated many new molecular genetic data derived from gene expression profiling and next generation sequencing studies, which refine the definition and diagnostic criteria of several entities. Nevertheless, the distinction of PTCL from various reactive conditions, and the diagnosis of PTCL subtypes remains notably challenging. Here, an updated summary of the clinicopathological and molecular features of the most common nodal-based PTCLs (angioimmunoblastic T-cell lymphoma and other nodal lymphomas derived from follicular T helper cells, anaplastic large cell lymphomas and peripheral T-cell lymphoma, not otherwise specified) is presented. Practical recommendations in the diagnostic approach to nodal T-cell lymphoproliferations are presented, including indications for the appropriate use and interpretation of ancillary studies. Finally, we discuss commonly encountered diagnostic problems, including pitfalls and mimics in the differential diagnosis with various reactive conditions, and the criteria that allow proper identification of distinct PTCL entities.
Keywords
Diagnosis, Differential, Gene Expression/physiology, Gene Expression Profiling/methods, Humans, Lymphoma, Large-Cell, Anaplastic/diagnosis, Lymphoma, Large-Cell, Anaplastic/pathology, Lymphoma, T-Cell/diagnosis, Lymphoma, T-Cell/pathology, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/pathology, FISH, T-cell lymphoma, angioimmunoblastic, differential diagnosis, immunohistochemistry, lymph node, mutations
Pubmed
Web of science
Open Access
Yes
Create date
02/12/2019 11:23
Last modification date
14/08/2020 6:21
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