Effects of nonhypotensive endotoxemia in conscious rats: role of prostaglandins.

Details

Serval ID
serval:BIB_BE44CB67EEB5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of nonhypotensive endotoxemia in conscious rats: role of prostaglandins.
Journal
American Journal of Physiology. Heart and Circulatory Physiology
Author(s)
Burnier M., Waeber B., Aubert J.F., Nussberger J., Brunner H.R.
ISSN
0363-6135
ISSN-L
0363-6135
Publication state
Published
Issued date
1988
Volume
254
Number
3 Pt 2
Pages
H509-H516
Language
english
Notes
Publication types: Journal Article
Abstract
A nonhypotensive dose of endotoxin was administered to normal conscious rats to evaluate the vascular and humoral effects of endotoxemia per se. Mean blood pressure and heart rate remained stable during the 45 min infusion of Escherichia coli endotoxin (0.01 mg/min). However, a marked increase in plasma renin activity (4.2 +/- 0.48 vs. 30.2 +/- 6 ng.ml-1.h-1, mean +/- SE, P less than 0.01), plasma epinephrine (0.112 +/- 0.04 vs. 1.71 +/- 0.5 ng/ml, P less than 0.01), and plasma norepinephrine (0.269 +/- 0.028 vs. 1.3 +/- 0.2 ng/ml, P less than 0.001) was observed during infusion in endotoxin-treated rats when compared with the vehicle-treated animals. In addition, the blood pressure response to exogenous norepinephrine was significantly reduced during nonhypotensive endotoxemia. Significant changes in regional blood flow distribution, as assessed by radiolabeled microspheres, were observed in endotoxemic rats; in particular a decrease in renal blood flow (7.39 +/- 0.43 vs. 5.97 +/- 0.4 ml.min-1.g-1, P less than 0.05) and an increase in coronary blood flow (5.01 +/- 0.38 vs. 6.44 +/- 0.33 ml.min-1.g-1, P less than 0.01) were found. The role of prostaglandins in the vascular and humoral alterations induced by nonhypotensive endotoxemia was also examined. Pretreatment with indomethacin (5 mg) prevented the increase in plasma renin activity as well as plasma catecholamine levels. On the contrary, the decreased vascular reactivity and the reduction in renal blood flow observed during endotoxemia were not affected by prostaglandin synthesis inhibition. Thus significant vascular and humoral changes have been found during endotoxemia even in absence of hypotension.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Animals, Consciousness, Cyclooxygenase Inhibitors, Endotoxins, Epinephrine, Escherichia coli, Hemodynamics, Indomethacin, Male, Norepinephrine, Prostaglandin Antagonists, Prostaglandins, Rats, Rats, Inbred Strains, Renin
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 15:32
Usage data