Effect of Growth Hormone on Endometrial Thickness and Fertility Outcome in the Treatment of Women with Panhypopituitarism: A Case Report.

Details

Serval ID
serval:BIB_BE30B6344FA9
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Effect of Growth Hormone on Endometrial Thickness and Fertility Outcome in the Treatment of Women with Panhypopituitarism: A Case Report.
Journal
The Journal of reproductive medicine
Author(s)
Drakopoulos P., Pluchino N., Bischof P., Cantero P., Meyer P., Chardonnens D.
ISSN
0024-7758 (Print)
ISSN-L
0024-7758
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
61
Number
1-2
Pages
78-82
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
The role of growth hormone (GH) in female reproduction has become a topic of increasing interest over the last decade. The replacement of GH for ovulation induction in women with hypopituitarism remains controversial. The role of GH in the human endometrium is still largely unknown. To the best of our knowledge, this study represents the first case report showing evidence that GH might play a role not only for ovulation induction, but also for the development of endometrial thickness in women with hypopituitarism.
A 32-year-old hypophysectomized. woman, known for primary infertility, experienced multiple IVF/embryo transfer failures with inadequate endometrial development. The use of GH replacement therapy followed by conventional controlled ovarian hyperstimulation enabled endometrial development and better ovarian response to gonadotropins, leading to a successful ongoing pregnancy.
The substitution with GH resulted in fewer days of ovarian stimulation, an acceptable endometrium, and a twin pregnancy delivered at 38 weeks' gestation.
Keywords
Adult, Endometrium/drug effects, Female, Growth Hormone/pharmacology, Growth Hormone/therapeutic use, Humans, Hypopituitarism/drug therapy, Pregnancy, Pregnancy Outcome
Pubmed
Web of science
Create date
15/09/2023 12:24
Last modification date
27/09/2023 8:45
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