Association entre lipoprotéine(a) et maladie coronarienne. [Association between lipoprotein(a) and coronary disease]

Details

Serval ID
serval:BIB_BE25D99F3F8C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association entre lipoprotéine(a) et maladie coronarienne. [Association between lipoprotein(a) and coronary disease]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Bovet P., Burnand B., Kappenberger L., Riesen W., Darioli R.
ISSN
0036-7672
ISSN-L
0036-7672
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
123
Number
45
Pages
2138-2146
Language
french
Abstract
The relationship of serum lipoprotein(a) [Lp(a)] to ischemic heart disease was investigated in a series of 114 men undergoing elective diagnostic coronary angiography at the University Hospital of Lausanne (Switzerland). Serum Lp(a) was higher (median: 134 mg/l; mean +/- SD: 371 +/- 509 mg/l) in the 76 individuals with ischemic heart disease, as defined by at least one significant stenosis (> or = 50%) in a proximal segment of a major coronary artery, compared to the 38 individuals without significant stenosis (60 mg/l; 155 +/- 218 mg/l). The risk ratio for ischemic heart disease was 4.2 (95% CI: 1.05-16.6) for serum Lp(a) greater than 300 mg/l compared to concentrations smaller than 50 mg/l, after adjustment for total cholesterol, HDL-cholesterol, body mass index, cigarette smoking, hypertension, and age. Lp(a) was the strongest lipid correlate of a severity score for coronary atherosclerosis (Jenkins' score) after adjustment for the other considered risk factors (partial R squared = 0.10; p < 0.001). These data are consistent with a strong independent effect of Lp(a) on ischemic heart disease. The literature on Lp(a) is reviewed and a clinical approach proposed.
Keywords
Body Mass Index, Cholesterol, Cholesterol, HDL, Coronary Angiography, Coronary Disease, Humans, Lipoprotein(a), Male, Middle Aged, Risk Factors, Smoking
Pubmed
Web of science
Create date
28/01/2008 11:45
Last modification date
20/08/2019 15:32
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