Potentially inappropriate medications in older adults living with HIV

Details

Serval ID
serval:BIB_BE22A9BED55E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Potentially inappropriate medications in older adults living with HIV
Journal
HIV Med
Author(s)
Lopez-Centeno B., Badenes-Olmedo C., Mataix-Sanjuan A., Bellon J. M., Perez-Latorre L., Lopez J. C., Benedi J., Khoo S., Marzolini C., Calvo-Alcantara M. J., Berenguer J.
ISSN
1468-1293 (Electronic)
ISSN-L
1464-2662
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
21
Number
8
Pages
541-546
Language
english
Notes
Lopez-Centeno, B
Badenes-Olmedo, C
Mataix-Sanjuan, A
Bellon, J M
Perez-Latorre, L
Lopez, J C
Benedi, J
Khoo, S
Marzolini, C
Calvo-Alcantara, M J
Berenguer, J
eng
MR/V020498/1/MRC_/Medical Research Council/United Kingdom
IISP 54912/Merck Sharp & Dohme Investigator Studies Program/
RD16/0025/0017/Instituto de Salud Carlos III-Subdireccion General de Evaluacion/
FondoEuropeo de Desarrollo Regional/
Research Support, Non-U.S. Gov't
England
HIV Med. 2020 Sep;21(8):541-546. doi: 10.1111/hiv.12883. Epub 2020 Jun 9.
Abstract
OBJECTIVES: We assessed the prevalence of potentially inappropriate medication (PIM) among older (>/= 65 years) people living with HIV (O-PLWH) in the region of Madrid. METHODS: We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. RESULTS: A total of 6 636 451 individuals received medications. Of these individuals, 22 945 received antiretrovirals (ARVs), and of these 1292 were O-PLWH. Overall, 1135 (87.8%) O-PLWH were taking at least one co-medication, and polypharmacy (at least five co-medications) was observed in 852 individuals (65.9%). A PIM was identified in 482 (37.3%) O-PLWH. Factors independently associated with PIM were polypharmacy [adjusted odds ratio (aOR) 7.08; 95% confidence interval (CI) 5.16-9.72] and female sex (aOR 1.75; 95% CI 1.30-2.35). The distribution of PIMs according to ATC drug class were nervous system drugs (n = 369; 28.6%), musculoskeletal system drugs (n = 140; 10.8%), gastrointestinal and metabolism drugs (n = 72; 5.6%), cardiovascular drugs (n = 61; 4.7%), respiratory system drugs (n = 13; 1.0%), antineoplastic and immunomodulating drugs (n = 10; 0.8%), and systemic anti-infectives (n = 2; 0.2%). Five drugs accounted for 84.8% of the 482O PLWH with PIMs: lorazepam (38.2%), ibuprofen (18.0%), diazepam (10.2%), metoclopramide (9.9%), and zolpidem (8.5%). CONCLUSIONS: Prescription of PIMs is highly prevalent in O-PLWH. Consistent with data in uninfected elderly people, the most frequently observed PIMs were benzodiazepines and nonsteroidal anti-inflammatory drugs . Targeted interventions are warranted to reduce inappropriate prescribing and polypharmacy in this vulnerable population.
Keywords
Aged, Aged, 80 and over, Comorbidity, Cross-Sectional Studies, Female, HIV Infections/*drug therapy/epidemiology, Humans, Inappropriate Prescribing/*statistics & numerical data, Male, Polypharmacy, Potentially Inappropriate Medication List/*statistics & numerical data, Prevalence, Retrospective Studies, Sex Factors, Spain/epidemiology, Hiv, aging, antiretroviral drugs, potentially inappropriate medication
Pubmed
Create date
25/08/2023 5:17
Last modification date
27/08/2023 6:01
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