Traitement de la crise hypertensive par le captopril. [Treatment of hypertensive crisis with captopril]

Details

Serval ID
serval:BIB_BDF348264511
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Traitement de la crise hypertensive par le captopril. [Treatment of hypertensive crisis with captopril]
Journal
Schweizerische Medizinische Wochenschrift
Author(s)
Biollaz  J., Waeber  B., Turini  G. A., Schaller  M. D., Brunner  H. R.
ISSN
0036-7672 (Print)
Publication state
Published
Issued date
12/1983
Volume
113
Number
52
Pages
2006-7
Notes
English Abstract
Journal Article --- Old month value: Dec 31
Abstract
The usefulness of captopril in managing hypertensive emergencies was evaluated in 9 untreated patients. During the 30 minutes following oral administration of 25 mg of this angiotensin converting enzyme inhibitor, blood pressure decreased from 239/134 to 204/118 mm Hg (p less than 0.05). At that time, furosemide (20 mg i.v. or 40 mg orally) had to be added in 5 patients to further decrease pressure levels. Ninety to 120 minutes after starting therapy, an additional dose of captopril (100 mg orally) was given to all patients. 12 and 24 hours after admission respectively, blood pressure averaged 140/93 and 139/86 mm Hg in the patients treated with captopril alone and 166/107 and 153/91 mm Hg in those treated with both captopril and furosemide. The blood pressure fall was well tolerated and no adverse effect was induced by captopril. These results show that captopril given alone or in association with a diuretic makes it possible to deal quickly and effectively with hypertensive crises without necessarily requiring monitoring in an intensive care unit.
Keywords
Administration, Oral Aged Blood Pressure/drug effects Captopril/administration & dosage/*therapeutic use Drug Therapy, Combination Female Furosemide/administration & dosage Humans Hypertension/*drug therapy Male Middle Aged Proline/*analogs & derivatives
Pubmed
Web of science
Create date
25/01/2008 10:41
Last modification date
20/08/2019 15:32
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