Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study.

Details

Serval ID
serval:BIB_BDB8C15FA6EB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study.
Journal
European child & adolescent psychiatry
Author(s)
Bond M., Moll N., Rosello A., Bond R., Schnell J., Burger B., Hoekstra P.J., Dietrich A., Schrag A., Kocovska E., Martino D., Mueller N., Schwarz M., Meier U.C.
Working group(s)
EMTICS Collaborative Group
Contributor(s)
Bruun J.E., Grejsen J., Ommundsen C.L., Rubæk M., Enghardt S., Bokemeyer S., Driedger-Garbe C., Reichert C., Schmalfeld J., Duffield T., Gergye F., Kovacs M., Vidomusz R., Carmel M., Fennig S., Gev E., Keller N., Michaelovsky E., Nahon M., Regev C., Simcha T., Smollan G., Weizman A., Gagliardi G., Tallon M., Roazzi P., van den Ban E., de Bruijn SFTM, Driessen N., Lamerz A., Messchendorp M., Rath JJG, Sival NSD, Tromp N., Visscher F., de la Tourettes S.G., Cáceres M.T., Carrillo F., Gómez-Garre P., Vargas L., Gariup M., Stöber S., Apter A., Baglioni V., Ball J., Benaroya-Milshtein N., Bodmer B., Bond M., Bognar E., Burger B., Buse J., Cardona F., Vela M.C., Dietrich A., Debes N.M., Ferro M.C., Fremer C., Garcia-Delgar B., Gulisano M., Hagen A., Hagstrøm J., Hedderly T.J., Heyman I., Hoekstra P.J., Huyser C., Madruga-Garrido M., Marotta A., Martino D., Meier U.C., Mir P., Moll N., Morer A., Mueller N., Müller-Vahl K., Münchau A., Nagy P., Neri V., Openneer TJC, Pellico A., Vasco Á.P., Plessen K.J., Porcelli C., Redondo M., Rizzo R., Roessner V., Ruhrman D., Schnell JML, Schrag A., Schwarz M.J., Silvestri P.R., Skov L., Steinberg T., Gloor F.T., Tarnok Z., Tübing J., Turner V.L., Walitza S., Weidinger E., Woods M.L.
ISSN
1435-165X (Electronic)
ISSN-L
1018-8827
Publication state
Published
Issued date
13/04/2021
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
This study investigated whether vitamin D is associated with the presence or severity of chronic tic disorders and their psychiatric comorbidities. This cross-sectional study compared serum 25-hydroxyvitamin D [25(OH)D] (ng/ml) levels among three groups: children and adolescents (3-16 years) with CTD (n = 327); first-degree relatives (3-10 years) of individuals with CTD who were assessed for a period of up to 7 years for possible onset of tics and developed tics within this period (n = 31); and first-degree relatives who did not develop tics and were ≥ 10 years old at their last assessment (n = 93). The relationship between 25(OH)D and the presence and severity of tics, as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD), were analysed controlling for age, sex, season, centre, latitude, family relatedness, and comorbidities. When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). There was no association between 25(OH)D and tic severity. However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36-0.84, p = 0.01) and was inversely associated with ADHD symptom severity (β = - 2.52, 95% CI - 4.16-0.88, p < 0.01). In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.
Keywords
ADHD, OCD, Pediatrics, Tic disorder, Tourette, Vitamin D
Pubmed
Web of science
Open Access
Yes
Create date
20/07/2021 8:29
Last modification date
21/07/2021 6:40
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