Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence.

Details

Serval ID
serval:BIB_BD9C72C19FE4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Immunological pathogenesis of main age-related diseases and frailty: Role of immunosenescence.
Journal
European Geriatric Medicine
Author(s)
Lang PO, Mitchell W, Lapenna A, Pitts D, Aspinall R.
ISSN
1878-7649
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
1
Number
2
Pages
112-21
Language
english
Abstract
Nowadays, it is well known that with advancing age individuals are at an increased susceptibility to develop diseases such as Alzheimer's disease, infectious diseases, cancer, and osteoporosis. Ageing is associated with various changes in immune parameters: therefore many authors have postulated that these age-related diseases could be explained, at least in part, by an overall deregulation of the function of the immune system. Immunosenescence is the term usually used to describe the acquired dysfunctional immunity within the ageing population affecting both innate and adaptive immunity. The present review examines the close involvement of the immunosenescence in the pathogenesis of these main age-related clinical outcomes, insulin resistance and the frailty process.
Web of science
Create date
15/04/2015 9:36
Last modification date
20/08/2019 15:31
Usage data