Sensing of mammalian IL-17A regulates fungal adaptation and virulence.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
Serval ID
serval:BIB_BD122754A4F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sensing of mammalian IL-17A regulates fungal adaptation and virulence.
Journal
Nature Communications
Author(s)
Zelante T., Iannitti R.G., De Luca A., Arroyo J., Blanco N., Servillo G., Sanglard D., Reichard U., Palmer G.E., Latgè J.P., Puccetti P., Romani L.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2012
Volume
3
Number
683
Pages
1-10
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
Infections by opportunistic fungi have traditionally been viewed as the gross result of a pathogenic automatism, which makes a weakened host more vulnerable to microbial insults. However, fungal sensing of a host's immune environment might render this process more elaborate than previously appreciated. Here we show that interleukin (IL)-17A binds fungal cells, thus tackling both sides of the host-pathogen interaction in experimental settings of host colonization and/or chronic infection. Global transcriptional profiling reveals that IL-17A induces artificial nutrient starvation conditions in Candida albicans, resulting in a downregulation of the target of rapamycin signalling pathway and in an increase in autophagic responses and intracellular cAMP. The augmented adhesion and filamentous growth, also observed with Aspergillus fumigatus, eventually translates into enhanced biofilm formation and resistance to local antifungal defenses. This might exemplify a mechanism whereby fungi have evolved a means of sensing host immunity to ensure their own persistence in an immunologically dynamic environment.
Keywords
Adaptation, Physiological, Animals, Aspergillus fumigatus/immunology, Aspergillus fumigatus/pathogenicity, Autophagy, Candida albicans/immunology, Candida albicans/pathogenicity, Cyclic AMP/biosynthesis, Female, Gene Expression Profiling, Host-Pathogen Interactions, Interleukin-17/metabolism, Mice, Mice, Inbred C57BL, Signal Transduction, TOR Serine-Threonine Kinases/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2012 16:15
Last modification date
20/08/2019 16:31
Usage data