Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer

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State: Public
Version: Final published version
Serval ID
serval:BIB_BCFB133ABD49
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer
Journal
International Journal of Breast Cancer
Author(s)
Stravodimou A., Voutsadakis I.A.
ISSN
2090-3170 (Print)
2090-3189 (Electronic)
ISSN-L
2090-3189
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
2013
Pages
289563
Language
english
Notes
Publication types: Clinical Study ; other Identifiant PubMed Central: PMC3707237
Abstract
Background. An elevated platelet count is often associated with malignancies, and it has been confirmed as an adverse prognostic factor in various cancers including early stage breast cancer. We sought to determine if thrombocytosis is also a prognostic factor in metastatic breast cancer. Patients and Methods. The records of 165 metastatic breast cancer patients with complete follow-up that had thrombocytosis or normal platelet counts were reviewed. Kaplan-Meier curves were constructed, and the survivals of the two groups were compared using the LogRank test. A Cox regression analysis was used to determine if thrombocytosis is an independent factor for overall and progression free survival. Results. There was a statistically significant difference in overall and progression free survival favoring the normal platelets group (LogRank test P = 0.038 and 0.008, resp.). Thrombocytosis remained a significant adverse prognostic factor in multivariate analysis. Other independent prognostic factors for overall survival included age, ER/PR status, and grade. Conclusion. Thrombocytosis represents an independent adverse prognostic factor in patients with metastatic breast cancer. Thus metastatic breast cancer joins a range of cancers in which this easily measurable value can be used for clinical prognostication. Further use as a predictive value for specific treatments has a rationale and deserves to be investigated.
Pubmed
Open Access
Yes
Create date
11/07/2016 10:04
Last modification date
20/08/2019 15:31
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