Global Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
Secondary document(s)
Download: 2018_Jorgensen_Gene_IntJEnvironResPublicHealth_2385.pdf (1314.48 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_BCE46693B383
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Global Gene Expression Response in Peripheral Blood Cells of Petroleum Workers Exposed to Sub-Ppm Benzene Levels.
Journal
International Journal of Environmental Research and Public Health
Author(s)
Jørgensen K.M., Færgestad Mosleth E., Hovde Liland K., Hopf Nancy B., Holdhus R., Stavrum A.K., Gjertsen B.T., Kirkeleit J.
ISSN
1660-4601 (Electronic)
ISSN-L
1660-4601
Publication state
Published
Issued date
27/10/2018
Peer-reviewed
Oui
Volume
15
Number
11
Pages
2385
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Altered gene expression in pathways relevant to leukaemogenesis, as well as reduced levels of circulating lymphocytes, have been reported in workers that were exposed to benzene concentrations below 1 ppm. In this study, we analysed whole blood global gene expression patterns in a worker cohort with altered levels of T cells and immunoglobulins IgM and IgA at three time points; pre-shift, post-shift (after three days), and post-recovery (12 hours later). Eight benzene exposed tank workers performing maintenance work in crude oil cargo tanks with a mean benzene exposure of 0.3 ppm (range 0.1⁻0.5 ppm) and five referents considered to be unexposed were examined by gene expression arrays. By using our data as independent validation, we reanalysed selected genes that were reported to be altered from previous studies of workers being exposed to sub-ppm benzene levels Four out of six genes previously proposed as marker genes in chronically exposed workers separated benzene exposed workers from unexposed referents (CLEC5, ACSL1, PRG2, IFNB1). Even better separation of benzene exposed workers and referents was observed for short-term exposure for genes in the Jak-STAT pathway, particularly elevated expression of IL6 and reduced expression of IL19.
Keywords
Adult, Benzene/toxicity, Blood Cells/drug effects, Blood Cells/metabolism, Environmental Pollutants/toxicity, Female, Gene Expression Regulation/drug effects, Humans, Longitudinal Studies, Male, Middle Aged, Norway, Occupational Exposure/adverse effects, benzene, gene expression, immune response, inflammation, leukaemia risk, offshore, petroleum industry
Pubmed
Web of science
Open Access
Yes
Create date
07/11/2018 10:04
Last modification date
20/08/2019 15:31
Usage data