Ionic Regulation of T-Cell Function and Anti-Tumour Immunity.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_BCD9B8C1A1C9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Ionic Regulation of T-Cell Function and Anti-Tumour Immunity.
Journal
International journal of molecular sciences
Author(s)
Ginefra P., Carrasco Hope H., Spagna M., Zecchillo A., Vannini N.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
20/12/2021
Peer-reviewed
Oui
Volume
22
Number
24
Pages
13668
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The capacity of T cells to identify and kill cancer cells has become a central pillar of immune-based cancer therapies. However, T cells are characterized by a dysfunctional state in most tumours. A major obstacle for proper T-cell function is the metabolic constraints posed by the tumour microenvironment (TME). In the TME, T cells compete with cancer cells for macronutrients (sugar, proteins, and lipid) and micronutrients (vitamins and minerals/ions). While the role of macronutrients in T-cell activation and function is well characterized, the contribution of micronutrients and especially ions in anti-tumour T-cell activities is still under investigation. Notably, ions are important for most of the signalling pathways regulating T-cell anti-tumour function. In this review, we discuss the role of six biologically relevant ions in T-cell function and in anti-tumour immunity, elucidating potential strategies to adopt to improve immunotherapy via modulation of ion metabolism.
Keywords
T cell, immunomodulation, ions, nutrient competition, tumour microenvironment
Pubmed
Web of science
Open Access
Yes
Create date
04/01/2022 9:46
Last modification date
20/07/2022 7:12
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